The DOI matches its Crossref record; 169 of the 169 references it cites were found in a registry or an index.
Peptidomimetics for Receptor Ligands—Discovery, Development, and Medical Perspectives
Abstract
Peptides, as neurotransmitters, neuromodulators, and hormones, influence a multitude of physiological processes by signal transduction mediated through receptors. In addition, during the last 20 years their role in the appearance or maintenance of various diseases could be unequivocally proven. Agents that can imitate or block the biological functions of bioactive peptides (agonists or antagonists, respectively) can be considered as aids for the investigation of peptidergic systems and also as therapeutic agents. The suitability of bioactive peptides as therapeutic agents was examined after preliminary pharmacological experiments. It was thereby shown that based on their pharmacological properties, for example degradation by peptidases or poor bioavailability, they could be employed as drugs in only a few cases. To solve this problem peptidomimetics, compounds that act as substitutes for peptides in their interaction with receptors, have been synthesized. In comparison with native peptides they show higher metabolic stability, better bioavailability, and longer duration of action. Peptidomimetics with antagonistic properties were also developed within the range of these investigations. As a result, new types of treatment and therapy for a series of diseases are possible. Although peptidomimetics have been developed largely by empirical methods (e.g. modification of native peptides, optimization of lead structures), methods for rational design based on investigations into the structure of peptidepeptide receptor complexes and studies of conformation energies, among others, are gradually being established.
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The Current Status of Heterocyclic Combinatorial Libraries
Nefzi, A., Ostresh, J. M., & Houghten, R. A. (1997) · Chemical Reviews · doi:10.1021/cr960010b · Cited by 586
N-Methylation of Peptides: A New Perspective in Medicinal Chemistry
Chatterjee, J., Gilon, C., Hoffman, A., & Kessler, H. (2008) · Accounts of Chemical Research · doi:10.1021/ar8000603 · Cited by 577
N‐Methylation of Peptides and Proteins: An Important Element for Modulating Biological Functions
Chatterjee, J., Rechenmacher, F., & Kessler, H. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201205674 · Cited by 494
Orally Absorbed Cyclic Peptides
Nielsen, D. S., Shepherd, N. E., Xu, W., Lucke, A. J., Stoermer, M. J., & Fairlie, D. P. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00838 · Cited by 445
Single Turn Peptide Alpha Helices with Exceptional Stability in Water
Shepherd, N. E., Hoang, H. N., Abbenante, G., & Fairlie, D. P. (2005) · Journal of the American Chemical Society · doi:10.1021/ja0456003 · Cited by 326
Metadata
- Authors
- Giannis, A., & Kolter, T.
- Venue
- Angewandte Chemie International Edition in English
- Publisher
- Wiley
- Published
- 1993-09
- Volume
- 32
- Issue
- 9
- Pages
- 1244-1267
- ISSN
- 0570-0833 (ISSN-L)
- OpenAlex
- W2096048736
- Cited by
- 784
- References
- 169
- FWCI
- 13.61
- Type
- journal article
- Language
- en
- Open access
- closed
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