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The Key–Lock Theory and the Induced Fit Theory
Abstract
As a glove changes shape when a hand slips into it, so an enzyme changes its conformation on binding a ligand. This theory of induced fit extends the lock‐and‐key principle that Emil Fischer proposed exactly 100 years ago. The new theory proposed by D. E. Koshland, Jr. in 1958 allows one to explain regulation and cooperative effects, and adds some new specificity principles as well.
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Citations
Cited by
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Dunker, A. K., Lawson, J. D., Brown, C. J., Williams, R. M., Romero, P., Oh, J. S., Oldfield, C. J., Campen, A. M., Ratliff, C. M., Hipps, K. W., et al. (2001) · Journal of Molecular Graphics and Modelling · doi:10.1016/s1093-3263(00)00138-8 · Cited by 2,272
Separation of enantiomers by their enantiospecific interaction with achiral magnetic substrates
Banerjee-Ghosh, K., Ben Dor, O., Tassinari, F., Capua, E., Yochelis, S., Capua, A., Yang, S.-H., Parkin, S. S. P., Sarkar, S., Kronik, L., et al. (2018) · Science · doi:10.1126/science.aar4265 · Cited by 460
Describing sequence–ensemble relationships for intrinsically disordered proteins
Mao, A. H., Lyle, N., & Pappu, R. V. (2013) · Biochemical Journal · doi:10.1042/bj20121346 · Cited by 135
The Electron Spin as a Chiral Reagent
Metzger, T. S., Mishra, S., Bloom, B. P., Goren, N., Neubauer, A., Shmul, G., Wei, J., Yochelis, S., Tassinari, F., Fontanesi, C., et al. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201911400 · Cited by 103
Protein flexibility in drug discovery: from theory to computation.
Buonfiglio, R., Recanatini, M., & Masetti, M. (2015) · ChemMedChem · doi:10.1002/cmdc.201500086 · Cited by 73
Metadata
- Authors
- Koshland, D. E.
- Venue
- Angewandte Chemie International Edition in English
- Publisher
- Wiley
- Published
- 1995-01-03
- Volume
- 33
- Issue
- 23-24
- Pages
- 2375-2378
- ISSN
- 0570-0833 (ISSN-L)
- OpenAlex
- W2098208486
- Cited by
- 754
- References
- 0
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Key–Lock Theory and the Induced Fit Theory. https://app.cochat.ai/papers/10.1002/anie.199423751
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- Koshland, D. E. (1995). The Key–Lock Theory and the Induced Fit Theory. Angewandte Chemie International Edition in English. https://doi.org/10.1002/anie.199423751
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
