The DOI matches its Crossref record.
Total Synthesis of (–)‐Epothilone B: An Extension of the Suzuki Coupling Method and Insights into Structure–Activity Relationships of the Epothilones
Abstract
The highest biological activities displayed by epothilone-related compounds have been found for epothilone B (1) and a derivative that was prepared en route to the natural product. Key steps in the total synthesis were a Suzuki coupling providing a trisubstituted double bond in the macrocycle and its subsequent stereoselective epoxidation with dimethyldioxirane.
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Cited by
Chou, T.-C. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.3.10 · Cited by 5,163
Self-citationThe modification of natural products for medical use
Guo, Z. (2017) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2016.06.003 · Cited by 328
Metadata
- Authors
- Su, D., Meng, D., Bertinato, P., Balog, A., Sorensen, E. J., Danishefsky, S. J., Zheng, Y., Chou, T., He, L., & Horwitz, S. B.
- Venue
- Angewandte Chemie International Edition in English
- Publisher
- Wiley
- Published
- 1997-04-18
- Volume
- 36
- Issue
- 7
- Pages
- 757-759
- ISSN
- 0570-0833 (ISSN-L)
- OpenAlex
- W2069635625
- Cited by
- 164
- References
- 0
- FWCI
- 19.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Total Synthesis of (–)‐Epothilone B: An Extension of the Suzuki Coupling Method and Insights into Structure–Activity Relationships of the Epothilones. https://app.cochat.ai/papers/10.1002/anie.199707571
- The paper
- Su, D., Meng, D., Bertinato, P., Balog, A., Sorensen, E. J., Danishefsky, S. J., Zheng, Y., Chou, T., He, L., & Horwitz, S. B. (1997). Total Synthesis of (–)‐Epothilone B: An Extension of the Suzuki Coupling Method and Insights into Structure–Activity Relationships of the Epothilones. Angewandte Chemie International Edition in English. https://doi.org/10.1002/anie.199707571
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
