The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Small Molecules as Inhibitors of Cyclin‐Dependent Kinases
Abstract
Cell division (mitosis) is one of the basic requirements for multicellular oranisms. The capability of a cell to replicate enables a complex assembly to be created. Faulty regulation of the control mechanism in the cell cycle leads to an excessive cell proliferation and is the cause of cancer. The key position of the cyclin‐dependent kinases (CDKs) and their direct partners, as well as the fact that the majority of malign illnesses show defects in at least one of these key players of the cell cycle, is of great interest for the development of low‐molecular‐weight CDK inhibitors. In this Review an overview of the different structural classes of ATP‐competitive inhibitors of CDKs are given, whose devlopment was aimed at battling cancer. The Review shows how far the development of selective CDK inhibitors has progressed and to what extent the expectations for such drugs have so far been fulfilled.
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Cites
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Cited by
Discovery of a potent and selective inhibitor of cyclin-dependent kinase 4/6
Toogood, P. L., Harvey, P. J., Repine, J. T., Sheehan, D. J., VanderWel, S. N., Zhou, H., Keller, P. R., McNamara, D. J., Sherry, D., Zhu, T., et al. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm049354h · Cited by 513
Flexible Docking in Solution Using Metadynamics
Gervasio, F. L., Laio, A., & Parrinello, M. (2005) · Journal of the American Chemical Society · doi:10.1021/ja0445950 · Cited by 287
Metadata
- Authors
- Huwe, A., Mazitschek, R., & Giannis, A.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2003-05-14
- Volume
- 42
- Issue
- 19
- Pages
- 2122-2138
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2166317851
- Cited by
- 181
- References
- 10
- FWCI
- 9.96
- Type
- journal article
- Language
- en
- Open access
- closed
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