The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
A Synthetic Antithrombin III Binding Pentasaccharide Is Now a Drug! What Comes Next?
Abstract
Heparin is a sulfated glycosaminoglycan isolated from animal organs that has been used clinically as an antithrombotic agent since the 1940s. In the early 1980s it was discovered that a unique pentasaccharide domain in some heparin chains activates antithrombin III (AT‐III), a serine protease inhibitor that blocks thrombin and factor Xa in the coagulation cascade. Sanofi‐Synthélabo and Organon developed a synthetic analogue of this pentasaccharide. The resulting antithrombotic drug arixtra, which went on the market in the USA and Europe in 2002, shows superior antithrombotic activity and brings about AT‐III‐mediated activity against factor Xa exclusively. Structure‐based design has subsequently led to analogues with longer‐lasting activity, such as idraparinux, as well as novel conjugates and long oligosaccharides with specific anti‐Xa and antithrombin activities. The new drug candidates are more selective in their mode of action than heparin and less likely to induce thrombocytopenia.
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Cites
Cobalt(II)-Nitronyl Nitroxide Chains as Molecular Magnetic Nanowires
Caneschi, A., Gatteschi, D., Lalioti, N., Sangregorio, C., Sessoli, R., Venturi, G., Vindigni, A., Rettori, A., Pini, M. G., & Novak, M. A. (2001) · Angewandte Chemie International Edition · doi:10.1002/1521-3773(20010504)40:9<1670::aid-anie16700>3.3.co;2-h · Cited by 1,154
The anticoagulant activation of antithrombin by heparin
Jin, L., Abrahams, J. P., Skinner, R., Petitou, M., Pike, R. N., & Carrell, R. W. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14683 · Cited by 685
Self-citationHeparin-induced Thrombocytopenia: Towards Consensus
Warkentin, T. E., Chong, B. H., & Greinacher, A. (1998) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1614206 · Cited by 542
Evidence for a 3-O-sulfated D-glucosamine residue in the antithrombin-binding sequence of heparin.
Lindahl, U., Bäckström, G., Thunberg, L., & Leder, I. G. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.11.6551 · Cited by 498
Further characterization of the antithrombin-binding sequence in heparin
Thunberg, L., Bäckström, G., & Lindahl, U. (1982) · Carbohydrate Research · doi:10.1016/s0008-6215(00)81050-2 · Cited by 455
The Unique Antithrombin III Binding Domain of Heparin: A Lead to New Synthetic Antithrombotics
van Boeckel, C. A. A., & Petitou, M. (1993) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199316713 · Cited by 382
Self-citationAnticoagulant activities of heparin oligosaccharides and their neutralization by platelet factor 4
Lane, D. A., Denton, J., Flynn, A. M., Thunberg, L., & Lindahl, U. (1984) · Biochemical Journal · doi:10.1042/bj2180725 · Cited by 342
Synthesis of thrombin-inhibiting heparin mimetics without side effects
Petitou, M., Hérault, J.-P., Bernat, A., Driguez, P.-A., Duchaussoy, P., Lormeau, J.-C., & Herbert, J.-M. (1999) · Nature · doi:10.1038/18877 · Cited by 326
Self-citationThe molecular-weight-dependence of the anti-coagulant activity of heparin
Laurent, T. C., Tengblad, A., Thunberg, L., Höök, M., & Lindahl, U. (1978) · Biochemical Journal · doi:10.1042/bj1750691 · Cited by 273
Danielsson, A., Raub, E., Lindahl, U., & Björk, I. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)66735-3 · Cited by 252
Cited by
Polymer Therapeutics: Concepts and Applications
Haag, R., & Kratz, F. (2006) · Angewandte Chemie International Edition · doi:10.1002/anie.200502113 · Cited by 1,115
Structural Insights into Biological Roles of Protein-Glycosaminoglycan Interactions
Raman, R., Sasisekharan, V., & Sasisekharan, R. (2005) · Chemistry & Biology · doi:10.1016/j.chembiol.2004.11.020 · Cited by 434
Metadata
- Authors
- Petitou, M., & van Boeckel, C. A. A.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2004-06-09
- Volume
- 43
- Issue
- 24
- Pages
- 3118-3133
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2160715301
- Cited by
- 485
- References
- 24
- FWCI
- 12.08
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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