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Serine Octamer Reactions: Indicators of Prebiotic Relevance
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The earliest molecule of life? Chirally selective reactions relevant to the origin of homochiral life are undergone by serine. Chiral exchange between serine, glyceraldehyde, and glucose occurs, favoring the enantiomers (L-serine, D-sugars) present in modern living systems (see picture).
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“Moreover, (S)-Ser in these octamers can be substituted enantiospecifically by prebiotic molecules (notably D-sugars)”
From Possible chemical and physical scenarios towards biological homochirality (2022) · cites this paper as [545]
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- D. Zhang K. J. Koch W. A. Tao R. G. Cooks Proceedings of the 48th ASMS conference Long Beach CA 2000.
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Metadata
- Authors
- Takats, Z., Nanita, S. C., & Cooks, R. G.
- Affiliations
- Purdue University West Lafayette (US)
- ORCID
- Cooks, R. Graham
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2003-07-30
- Volume
- 42
- Issue
- 30
- Pages
- 3521-3523
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2090276084
- Cited by
- 107
- References
- 21
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 5 · 2021: 7 · 2020: 3 · 2018: 6 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 1 · 2013: 3 · 2012: 8
- FWCI
- 8.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Physical Sciences › Chemistry › Organic Chemistry › Asymmetric Synthesis and Catalysis
- Physical Sciences › Chemistry › Organic Chemistry › Physical Organic Chemistry and Reaction Kinetics
- Keywords
- serine, prebiotic chemistry, origin of homochirality, chirality, glyceraldehyde, glucose, L-serine, enantiomers, origin of life
- MeSH terms
- Glucose, Glyceraldehyde, Indicators and Reagents, Serine, Evolution, Chemical, Spectrometry, Mass, Electrospray Ionization
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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