The DOI matches its Crossref record.
Reevaluation of the Mechanism of the Baylis–Hillman Reaction: Implications for Asymmetric Catalysis
Abstract
One step beyond: Proton transfer (step 3, see scheme), not CC bond formation (step 2) as previously thought, is the rate-limiting step (RLS) in the initial stage of the Baylis–Hillman reaction, which involves the amine-catalyzed addition of an aldehyde to an activated alkene to generate an allylic alcohol. This finding has considerable implications for asymmetric catalysis of the reaction.
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Cited by
Alternative energy input: mechanochemical, microwave and ultrasound-assisted organic synthesis
Baig, R. B. N., & Varma, R. S. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15204a · Cited by 587
Amedjkouh, M., & Brandberg, M. (2008) · Chemical Communications · doi:10.1039/b804142n · Cited by 54
Metadata
- Authors
- Aggarwal, V. K., Fulford, S. Y., & Lloyd‐Jones, G. C.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2005-03-02
- Volume
- 44
- Issue
- 11
- Pages
- 1706-1708
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2158035214
- Cited by
- 243
- References
- 0
- FWCI
- 13.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- Aggarwal, V. K., Fulford, S. Y., & Lloyd‐Jones, G. C. (2005). Reevaluation of the Mechanism of the Baylis–Hillman Reaction: Implications for Asymmetric Catalysis. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.200462462
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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