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Ruthenium Half‐Sandwich Complexes Bound to Protein Kinase Pim‐1
Abstract
Keeping in shape with half a sandwich: The structure of a picomolar organoruthenium inhibitor bound to the ATP-binding site of the protein kinase Pim-1 (see picture) demonstrates that the ruthenium center has solely a structural role in organizing the organic ligands in the three-dimensional receptor space, thus yielding a structure that is complementary in shape and functional group presentation to the active site of Pim-1.
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Citations
Cites
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Newman, D. J., Cragg, G. M., & Snader, K. M. (2000) · Natural Product Reports · doi:10.1039/a902202c · Cited by 1,293
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Bruijnincx, P. C., & Sadler, P. J. (2008) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2007.11.013 · Cited by 1,306
Occurrence, Biogenesis, and Synthesis of Biologically Active Carbazole Alkaloids
Schmidt, A. W., Reddy, K. R., & Knölker, H.-J. (2012) · Chemical Reviews · doi:10.1021/cr200447s · Cited by 1,243
Bioorganometallic chemistry—from teaching paradigms to medicinal applications
Hartinger, C. G., & Dyson, P. J. (2009) · Chem. Soc. Rev. · doi:10.1039/b707077m · Cited by 985
Antitumour metal compounds: more than theme and variations
Jakupec, M. A., Galanski, M. S., Arion, V. B., Hartinger, C. G., & Keppler, B. K. (2008) · Dalton Transactions · doi:10.1039/b712656p · Cited by 850
Recent developments in ruthenium anticancer drugs
Levina, A., Mitra, A., & Lay, P. A. (2009) · Metallomics · doi:10.1039/b904071d · Cited by 592
Metadata
- Authors
- Debreczeni, J. É., Bullock, A. N., Atilla, G. E., Williams, D. S., Bregman, H., Knapp, S., & Meggers, E.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2006-02-20
- Volume
- 45
- Issue
- 10
- Pages
- 1580-1585
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2103268811
- Cited by
- 234
- References
- 1
- FWCI
- 10.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- Debreczeni, J. É., Bullock, A. N., Atilla, G. E., Williams, D. S., Bregman, H., Knapp, S., & Meggers, E. (2006). Ruthenium Half‐Sandwich Complexes Bound to Protein Kinase Pim‐1. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.200503468
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
