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The Pursuit of Palau'amine
Abstract
Since its discovery in 1993, the marine natural product palau'amine has intrigued natural product chemists. Its exotic molecular architecture and purported bioactivity made it an ideal target for synthesis. However, as the years went by and related marine alkaloids were isolated, a skeptical eye was cast on the structure of palau'amine; recently these suspicions were confirmed and the structure of palau'amine revised. This Minireview gives a careful overview of the structural revision and its ramifications to both its biogenesis and total synthesis.
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Cited by
Protecting-group-free synthesis as an opportunity for invention
Young, I. S., & Baran, P. S. (2009) · Nature Chemistry · doi:10.1038/nchem.216 · Cited by 667
Self-citationBlunt, J. W., Copp, B. R., Hu, W.-P., Munro, M. H. G., Northcote, P. T., & Prinsep, M. R. (2009) · Natural Product Reports · doi:10.1039/b805113p · Cited by 520
Chemoselectivity: The Mother of Invention in Total Synthesis
Shenvi, R. A., O’Malley, D. P., & Baran, P. S. (2009) · Accounts of Chemical Research · doi:10.1021/ar800182r · Cited by 334
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Metadata
- Authors
- Köck, M., Grube, A., Seiple, I. B., & Baran, P. S.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2007-08-28
- Volume
- 46
- Issue
- 35
- Pages
- 6586-6594
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2166424054
- Cited by
- 159
- References
- 0
- FWCI
- 7.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Pursuit of Palau'amine. https://app.cochat.ai/papers/10.1002/anie.200701798
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- Köck, M., Grube, A., Seiple, I. B., & Baran, P. S. (2007). The Pursuit of Palau'amine. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.200701798
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