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An Efficient Fmoc‐SPPS Approach for the Generation of Thioester Peptide Precursors for Use in Native Chemical Ligation
Open accessAbstract
Intramolecular activation of C-terminal peptides: Mildly activated N-acylurea peptides are readily formed on the solid support following chain assembly, avoiding over-activation of the C-terminus. The utility of these peptides is demonstrated by the native chemical ligation of unprotected peptides (see scheme; R=amino acid side chain).
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Cites
Transvascular delivery of small interfering RNA to the central nervous system
Kumar, P., Wu, H., McBride, J. L., Jung, K.-E., Hee Kim, M., Davidson, B. L., Kyung Lee, S., Shankar, P., & Manjunath, N. (2007) · Nature · doi:10.1038/nature05901 · Cited by 1,246
Cited by
Advances in Fmoc solid‐phase peptide synthesis
Behrendt, R., White, P., & Offer, J. (2016) · Journal of Peptide Science · doi:10.1002/psc.2836 · Cited by 760
Native Chemical Ligation and Extended Methods: Mechanisms, Catalysis, Scope, and Limitations
Agouridas, V., El Mahdi, O., Diemer, V., Cargoët, M., Monbaliu, J.-C. M., & Melnyk, O. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00712 · Cited by 650
Expanding the chemical toolbox for the synthesis of large and uniquely modified proteins
Bondalapati, S., Jbara, M., & Brik, A. (2016) · Nature Chemistry · doi:10.1038/nchem.2476 · Cited by 359
Histones: At the Crossroads of Peptide and Protein Chemistry
Müller, M. M., & Muir, T. W. (2015) · Chemical Reviews · doi:10.1021/cr5003529 · Cited by 247
Functional Ambidexterity of an Ancient Nucleic Acid‐Binding Domain
Weil‐Ktorza, O., Naveh‐Tassa, S., Fridmann‐Sirkis, Y., Despotović, D., Cherukuri, K. P., Corlett, T., Levy, Y., Metanis, N., & Longo, L. M. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202505188 · Cited by 12
Metadata
- Authors
- Blanco‐Canosa, J. B., & Dawson, P. E.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2008-08-20
- Volume
- 47
- Issue
- 36
- Pages
- 6851-6855
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2161815395
- Cited by
- 512
- References
- 1
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Blanco‐Canosa, J. B., & Dawson, P. E. (2008). An Efficient Fmoc‐SPPS Approach for the Generation of Thioester Peptide Precursors for Use in Native Chemical Ligation. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.200705471
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