The DOI matches its Crossref record; 112 of the 112 references it cites were found in a registry or an index.
Synthesis of 11C, 18F, 15O, and 13N Radiolabels for Positron Emission Tomography
Abstract
Positron emission tomography (PET) is a powerful and rapidly developing area of molecular imaging that is used to study and visualize human physiology by the detection of positron‐emitting radiopharmaceuticals. Information about metabolism, receptor/enzyme function, and biochemical mechanisms in living tissue can be obtained directly from PET experiments. Unlike magnetic resonance imaging (MRI) or computerized tomography (CT), which mainly provide detailed anatomical images, PET can measure chemical changes that occur before macroscopic anatomical signs of a disease are observed. PET is emerging as a revolutionary method for measuring body function and tailoring disease treatment in living subjects. The development of synthetic strategies for the synthesis of new positron‐emitting molecules is, however, not trivial. This Review highlights key aspects of the synthesis of PET radiotracers with the short‐lived positron‐emitting radionuclides 11 C, 18 F, 15 O, and 13 N, with emphasis on the most recent strategies.
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Cites
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Cited by
‘Two is better than one’—probes for dual-modality molecular imaging
Jennings, L. E., & Long, N. J. (2009) · Chemical Communications · doi:10.1039/b821903f · Cited by 438
Self-citationYue, N.-N., Xu, H.-M., Xu, J., Zhu, M.-Z., Zhang, Y., Tian, C.-M., Nie, Y.-Q., Yao, J., Liang, Y.-J., Li, D.-F., et al. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s413141 · Cited by 46
Tago, T., & Toyohara, J. (2018) · Molecules · doi:10.3390/molecules23020300 · Cited by 28
Metadata
- Authors
- Miller, P. W., Long, N. J., Vilar, R., & Gee, A. D.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2008-11-05
- Volume
- 47
- Issue
- 47
- Pages
- 8998-9033
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2098735745
- Cited by
- 894
- References
- 112
- FWCI
- 27.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- Miller, P. W., Long, N. J., Vilar, R., & Gee, A. D. (2008). Synthesis of 11C, 18F, 15O, and 13N Radiolabels for Positron Emission Tomography. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.200800222
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