Hydrocyanines: A class of fluorescent sensors that can image reactive oxygen species in cell culture, tissue, and in vivo
Open accessAbstract
Accurate and tunable: The title compounds can detect reactive oxygen species (ROS) in cell culture, tissue explants, and for the first time in vivo. The hydrocyanines are synthesized by reduction of the cyanine dyes with NaBH4. They can accurately detect nanomolar levels of ROS, have excellent stability against autoxidation, and have tunable emission wavelengths in the range 560–830 nm.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Murthy's group found that hydrocyanines could be used to detect superoxide.
“Murthy’s group found that hydrocyanines could be used to detect the superoxide [168].”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [168]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 19 · Cited by 339
- Authors
- Kundu, K., Knight, S. F., Willett, N., Lee, S., Taylor, W. R., & Murthy, N.
- Affiliations
- Georgia Institute of Technology (US)
- Emory University (US)
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2008-12-22
- Volume
- 48
- Issue
- 2
- Pages
- 299-303
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- PMC
- PMC5935505
- OpenAlex
- W2121406617
- Cited by
- 339
- References
- 19
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 10 · 2023: 17 · 2022: 14 · 2021: 21 · 2020: 17 · 2019: 27 · 2018: 22 · 2017: 26 · 2016: 28 · 2015: 29 · 2014: 23 · 2013: 32 · 2012: 19
- FWCI
- 5.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5u01hl080711-05)
- National Heart, Lung, and Blood Institute (U01-HL080711, U01HL80711-01, R01HL096796)
- National Institute of Biomedical Imaging and Bioengineering (R21EB006418)
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Advanced Fluorescence Microscopy Techniques
- Keywords
- reactive oxygen species, fluorescent sensors, cyanine dyes, sodium borohydride reduction, tunable emission wavelength, in vivo imaging, tissue explants, cell culture imaging
- MeSH terms
- Animals, Aorta, Carbocyanines, Fluorescent Dyes, Muscle, Smooth, Vascular, Organ Culture Techniques, Sensitivity and Specificity, Spectrometry, Fluorescence, Molecular Structure, Reactive Oxygen Species, Cell Culture Techniques, Mice, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
