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Multistep Synthesis Using Modular Flow Reactors: Bestmann–Ohira Reagent for the Formation of Alkynes and Triazoles
Open accessAbstract
Multistep in flow: The Seyferth–Gilbert reagent 1 has been applied in a flow system to rapidly synthesize terminal alkynes. The system has been further applied to synthesize triazole 3 from alcohol 2 in a three‐step oxidation/homologation/copper(I)‐catalyzed azide–alkyne cycloaddition sequence without isolation of intermediates (see scheme).magnified image
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Self-citationFlow Ozonolysis Using a Semipermeable Teflon AF-2400 Membrane To Effect Gas−Liquid Contact
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Metadata
- Authors
- Baxendale, I. R., Ley, S. V., Mansfield, A. C., & Smith, C. D.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2009-05-12
- Volume
- 48
- Issue
- 22
- Pages
- 4017-4021
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2161653506
- Cited by
- 231
- References
- 0
- FWCI
- 21.16
- Type
- journal article
- Language
- en
- Open access
- green
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- Baxendale, I. R., Ley, S. V., Mansfield, A. C., & Smith, C. D. (2009). Multistep Synthesis Using Modular Flow Reactors: Bestmann–Ohira Reagent for the Formation of Alkynes and Triazoles. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.200900970
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