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Solvent‐Free Synthesis of Peptides
Open accessAbstract
A crush on sweetness! The coupling of a urethane-protected N-carboxyanhydride of an amino acid with another amino acid derivative under ball-milling conditions gives a protected dipeptide in very high yield (see scheme; PG: protecting group). The reaction takes place in the solid state. The synthesis was applied to the preparation of a tripeptide and the sweetener aspartame, without any organic solvent or purification.
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Citations
Cited by
Alternative energy input: mechanochemical, microwave and ultrasound-assisted organic synthesis
Baig, R. B. N., & Varma, R. S. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15204a · Cited by 587
Kachala, V. V., Khemchyan, L. L., Kashin, A. S., Orlov, N. V., Grachev, A. A., Zalesskiy, S. S., & Ananikov, V. P. (2013) · Russian Chemical Reviews · doi:10.1070/rc2013v082n07abeh004413 · Cited by 262
The greening of peptide synthesis
Lawrenson, S. B., Arav, R., & North, M. (2017) · Green Chemistry · doi:10.1039/c7gc00247e · Cited by 205
Controlled Solid Phase Peptide Bond Formation Using N-Carboxyanhydrides and PEG Resins in Water.
De Marco, R., Tolomelli, A., Greco, A., & Gentilucci, L. (2013) · ACS Sustainable Chemistry & Engineering · doi:10.1021/sc400058r · Cited by 38
Metadata
- Authors
- Declerck, V., Nun, P., Martinez, J., & Lamaty, F.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2009-11-17
- Volume
- 48
- Issue
- 49
- Pages
- 9318-9321
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2071905449
- Cited by
- 204
- References
- 0
- FWCI
- 2.88
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Declerck, V., Nun, P., Martinez, J., & Lamaty, F. (2009). Solvent‐Free Synthesis of Peptides. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.200903510
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
