The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
An Integrated Microreactor System for Self‐Optimization of a Heck Reaction: From Micro‐ to Mesoscale Flow Systems
Abstract
Set it and forget it: The combination of feedback control and continuous-flow operations in microreactors (see picture) enables online and fully automated reaction optimization. A Heck reaction demonstrates the potential for rapid multivariable reaction optimization while requiring a minimal amount of material. Optimal conditions are quickly scaled-up by a factor of 50.
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Citations
Cites
A Simplex Method for Function Minimization
Nelder, J. A., & Mead, R. (1965) · The Computer Journal · doi:10.1093/comjnl/7.4.308 · Cited by 28,905
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Plutschack, M. B., Pieber, B., Gilmore, K., & Seeberger, P. H. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00183 · Cited by 1,995
The past, present and potential for microfluidic reactor technology in chemical synthesis
Elvira, K. S., i Solvas, X. C., Wootton, R. C. R., & deMello, A. J. (2013) · Nature Chemistry · doi:10.1038/nchem.1753 · Cited by 1,203
Schneider, G. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.232 · Cited by 910
Self-Driving Laboratories for Chemistry and Materials Science
Tom, G., Schmid, S. P., Baird, S. G., Cao, Y., Darvish, K., Hao, H., Lo, S., Pablo-García, S., Rajaonson, E. M., Skreta, M., et al. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.4c00055 · Cited by 707
Continuous flow reactors: a perspective
Wiles, C., & Watts, P. (2012) · Green Chem. · doi:10.1039/c1gc16022b · Cited by 626
Metadata
- Authors
- McMullen, J. P., Stone, M. T., Buchwald, S. L., & Jensen, K. F.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2010-08-19
- Volume
- 49
- Issue
- 39
- Pages
- 7076-7080
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2163028913
- Cited by
- 222
- References
- 1
- FWCI
- 10.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- McMullen, J. P., Stone, M. T., Buchwald, S. L., & Jensen, K. F. (2010). An Integrated Microreactor System for Self‐Optimization of a Heck Reaction: From Micro‐ to Mesoscale Flow Systems. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201002590
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
