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Dearomatization Strategies in the Synthesis of Complex Natural Products
Open accessAbstract
Evolution in the field of the total synthesis of natural products has led to exciting developments over the last decade. Numerous chemoselective and enantioselective methodologies have emerged from total syntheses, resulting in efficient access to many important natural product targets. This Review highlights recent developments concerning dearomatization, a powerful strategy for the total synthesis of architecturally complex natural products wherein planar, aromatic scaffolds are converted to three‐dimensional molecular architectures.
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Cites
Nucleus-Independent Chemical Shifts (NICS) as an Aromaticity Criterion
Chen, Z., Wannere, C. S., Corminboeuf, C., Puchta, R., & Schleyer, P. V. R. (2005) · Chemical Reviews · doi:10.1021/cr030088+ · Cited by 3,847
Cited by
All-carbon quaternary centers in natural products and medicinal chemistry: recent advances
Ling, T., & Rivas, F. (2016) · Tetrahedron · doi:10.1016/j.tet.2016.09.002 · Cited by 312
Zhu, M., Zheng, C., Zhang, X., & You, S.-L. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.8b12965 · Cited by 298
Metadata
- Authors
- Roche, S. P., & Porco, J. A.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2011-04-19
- Volume
- 50
- Issue
- 18
- Pages
- 4068-4093
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2099439117
- Cited by
- 1,327
- References
- 1
- FWCI
- 30.22
- Type
- journal article
- Language
- en
- Open access
- green
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- Roche, S. P., & Porco, J. A. (2011). Dearomatization Strategies in the Synthesis of Complex Natural Products. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201006017
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