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Squaramides as Potent Transmembrane Anion Transporters

Busschaert, Nathalie, Kirby, Isabelle L., Young, Sarah, Coles, Simon J., Horton, Peter N., Light, Mark E., Gale, Philip A.·2012·Angewandte Chemie International Edition
DOI 10.1002/anie.201200729
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Abstract

Square peg in a round ball: Squaramides are shown to be potent transmembrane anion transporters for both chloride and bicarbonate, performing better than the thiourea and urea analogues. Studies into the nature of this transport point to a mobile carrier mechanism, where the squaramide delivers the anion cargo across the lipid bilayer (see scheme, green sphere=anion). These drug-like molecules provide a platform for the development of a new generation of anion-transport systems.

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Crossref · 10.1002/anie.201200729

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  • Compound 19 is known to promote the transport of chloride out of lipid vesicles.

    “To evaluate this hypothesis we examined 19 (Figure 3), which is a compound known to promote the transport of chloride out of lipid vesicles (Busschaert et al., 2012).”

    From Small Molecule Fluoride Toxicity Agonists (2015) · cites this paper as Busschaert et al., 2012

  • Incorporation of fluorine and trifluoromethyl substituents onto aryl rings of small molecule chloride binders is known to improve their ability to transport chloride across phospholipid membranes.

    “Furthermore, incorporation of fluorine and trifluoromethyl substituents onto aryl rings of small molecule chloride binders is known to improve their ability to transport chloride across phospholipid membranes (Busschaert et al., 2011; Busschaert et al., 2012).”

    From Small Molecule Fluoride Toxicity Agonists (2015) · cites this paper as Busschaert et al., 2012

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Metadata

Authors
Busschaert, N., Kirby, I. L., Young, S., Coles, S. J., Horton, P. N., Light, M. E., & Gale, P. A.
Venue
Angewandte Chemie International Edition
Publisher
Wiley
Published
2012-03-27
Volume
51
Issue
18
Pages
4426-4430
ISSN
  • 1433-7851
  • 1521-3773
DOI
10.1002/anie.201200729
Cited by
269
References
0
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

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