The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Orally Active Peptidic Bradykinin B1 Receptor Antagonists Engineered from a Cyclotide Scaffold for Inflammatory Pain Treatment
Abstract
Edible: By grafting natural peptide antagonists onto the cyclotide kalata B1, orally active peptides were engineered, which are potentially useful therapeutics for the treatment of inflammatory pain. For example, the entire loop 6 of kalata B1 was replaced with the peptidic bradykinin B1 receptor antagonist DALK (red in scheme) to obtain the cyclic bradykinin antagonist ckb-kal.
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Citations
Cites
Management of Chronic Pain in Cancer Survivors
Levy, M. H., Chwistek, M., & Mehta, R. S. (2008) · The Cancer Journal · doi:10.1097/ppo.0b013e31818f5aa7 · Cited by 125
Cited by
The Current State of Peptide Drug Discovery: Back to the Future?
Henninot, A., Collins, J. C., & Nuss, J. M. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00318 · Cited by 1,113
Multifaceted Roles of Disulfide Bonds. Peptides as Therapeutics
Góngora-Benítez, M., Tulla-Puche, J., & Albericio, F. (2014) · Chemical Reviews · doi:10.1021/cr400031z · Cited by 655
Antimicrobial Peptides from Plants
Tam, J., Wang, S., Wong, K., & Tan, W. (2015) · Pharmaceuticals · doi:10.3390/ph8040711 · Cited by 489
Self-citationOrally Absorbed Cyclic Peptides
Nielsen, D. S., Shepherd, N. E., Xu, W., Lucke, A. J., Stoermer, M. J., & Fairlie, D. P. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00838 · Cited by 445
Butelase 1 is an Asx-specific ligase enabling peptide macrocyclization and synthesis
Nguyen, G. K. T., Wang, S., Qiu, Y., Hemu, X., Lian, Y., & Tam, J. P. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1586 · Cited by 431
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Metadata
- Authors
- Wong, C. T. T., Rowlands, D. K., Wong, C., Lo, T. W. C., Nguyen, G. K. T., Li, H., & Tam, J. P.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2012-04-24
- Volume
- 51
- Issue
- 23
- Pages
- 5620-5624
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2118384592
- Cited by
- 229
- References
- 1
- FWCI
- 8.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Orally Active Peptidic Bradykinin B1 Receptor Antagonists Engineered from a Cyclotide Scaffold for Inflammatory Pain Treatment. https://app.cochat.ai/papers/10.1002/anie.201200984
- The paper
- Wong, C. T. T., Rowlands, D. K., Wong, C., Lo, T. W. C., Nguyen, G. K. T., Li, H., & Tam, J. P. (2012). Orally Active Peptidic Bradykinin B1 Receptor Antagonists Engineered from a Cyclotide Scaffold for Inflammatory Pain Treatment. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201200984
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
