Reactions Templated by Nucleic Acids: More Ways to Translate Oligonucleotide‐Based Instructions into Emerging Function
Open accessAbstract
The programmability of oligonucleotide recognition offers an attractive platform to direct the assembly of reactive partners that can engage in chemical reactions. Recently, significant progress has been made in both the breadth of chemical transformations and in the functional output of the reaction. Herein we summarize these recent progresses and illustrate their applications to translate oligonucleotide instructions into functional materials and novel architectures (conductive polymers, nanopatterns, novel oligonucleotide junctions); into fluorescent or bioactive molecule using cellular RNA; to interrogate secondary structures or oligonucelic acids; or a synthetic oligomer.
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Several DNA-templated reactions with longer probes proceed within minutes at very low concentrations, benefiting from high effective concentrations in stable hybridization complexes.
“In contrast, several DNA-templated reactions with longer probes have been shown to proceed within minutes at very low concentrations, benefiting from high effective concentrations in stable hybridization complexes.18−20”
From Sequencing of <scp>d</scp>/<scp>l</scp>-DNA and XNA by Templated-Synthesis (2025) · cites this paper as [19]
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References 171 · Cited by 155
- Authors
- Gorska, K., & Winssinger, N.
- Affiliations
- University of Geneva (CH)
- Corresponding author
- Winssinger, Nicolas
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2013-06-12
- Volume
- 52
- Issue
- 27
- Pages
- 6820-6843
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2100759999
- Cited by
- 155
- References
- 171
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 7 · 2023: 5 · 2022: 10 · 2021: 10 · 2020: 17 · 2019: 11 · 2018: 11 · 2017: 17 · 2016: 13 · 2015: 12 · 2014: 16 · 2013: 9
- FWCI
- 1.57
- Type
- journal article
- Language
- en
- Open access
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Keywords
- conducting polymers, nanopatterning, bioactive compounds, RNA secondary structure, functional materials
- MeSH terms
- Nucleic Acid Hybridization, Nucleic Acids, Oligonucleotides
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