Poly(norepinephrine): Ultrasmooth Material‐Independent Surface Chemistry and Nanodepot for Nitric Oxide
Abstract
Capture and release: The material-independent surface chemistry of a poly(norepinephrine) (pNE) which exhibits perfect smoothness at the nanometer scale is controlled by 3,4-dihydroxybenzaldehyde-norepinephrine (DHBA-NE) conjugates. The pNE layer containing DHBA-NE serves to store and release small therapeutics such as nitric oxide.
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Hydroxyl groups in the donor molecule or its matrix can hydrogen-bond with diazeniumdiolates.
“It has also been reported that hydroxyl groups within the donor molecule, or the matrix it is within, can also contribute to the hydrogen bonding with the diazeniumdiolates.149,150”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [150]
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References 52 · Cited by 257
- Authors
- Hong, S., Kim, J., Na, Y. S., Park, J., Kim, S., Singha, K., Im, G., Han, D., Kim, W. J., & Lee, H.
- Affiliations
- Korea Advanced Institute of Science and Technology (KR)
- Pohang University of Science and Technology (KR)
- Dongguk University Ilsan Hospital (KR)
- Korea Institute of Science and Technology (KR)
- Corresponding author
- Kim, Won Jong
- Lee, Haeshin
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2013-07-10
- Volume
- 52
- Issue
- 35
- Pages
- 9187-9191
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2118805699
- Cited by
- 257
- References
- 52
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 17 · 2023: 11 · 2022: 22 · 2021: 29 · 2020: 22 · 2019: 24 · 2018: 21 · 2017: 24 · 2016: 26 · 2015: 16 · 2014: 18 · 2013: 4
- FWCI
- 8.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Open Access System for Information Sharing (Pohang University of Science and Technology) (submittedVersion)
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Keywords
- ultra-smooth surfaces, nitric oxide delivery, controlled release, drug storage, biomaterials
- MeSH terms
- Nitric Oxide, Norepinephrine, Particle Size, Polymers, Surface Properties, Molecular Structure, Nanostructures
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