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Cited by 225

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Concurrent Block Copolymer Polymersome Stabilization and Bilayer Permeabilization by Stimuli‐Regulated “Traceless” Crosslinking

Wang, Xiaorui, Liu, Guhuan, Hu, Jinming, Zhang, Guoying, Liu, Shiyong·2014·Angewandte Chemie International Edition

Abstract

The fabrication of block copolymer (BCP) vesicles (polymersomes) exhibiting synchronized covalent crosslinking and bilayer permeabilization remains a considerable challenge as crosslinking typically leads to compromised membrane permeability. Herein it is demonstrated how to solve this dilemma by employing a stimuli‐triggered crosslinking strategy with amphiphilic BCPs containing photolabile carbamate‐caged primary amines. Upon self‐assembling into polymersomes, light‐triggered self‐immolative decaging reactions release primary amine moieties and extensive amidation reactions then occur due to suppressed amine p Ka within hydrophobic milieu. This leads to serendipitous vesicle crosslinking and the process is associated with bilayer hydrophobicity‐to‐hydrophilicity transition and membrane permeabilization.

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Metadata

Authors
Wang, X., Liu, G., Hu, J., Zhang, G., & Liu, S.
Venue
Angewandte Chemie International Edition
Publisher
Wiley
Published
2014-02-12
Volume
53
Issue
12
Pages
3138-3142
ISSN
  • 1433-7851 (ISSN-L)
  • 1521-3773
OpenAlex
W2136476605
Cited by
225
References
2
FWCI
12.57
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Concurrent Block Copolymer Polymersome Stabilization and Bilayer Permeabilization by Stimuli‐Regulated “Traceless” Crosslinking. https://app.cochat.ai/papers/10.1002/anie.201310589
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Wang, X., Liu, G., Hu, J., Zhang, G., & Liu, S. (2014). Concurrent Block Copolymer Polymersome Stabilization and Bilayer Permeabilization by Stimuli‐Regulated “Traceless” Crosslinking. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201310589

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