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Concurrent Block Copolymer Polymersome Stabilization and Bilayer Permeabilization by Stimuli‐Regulated “Traceless” Crosslinking
Abstract
The fabrication of block copolymer (BCP) vesicles (polymersomes) exhibiting synchronized covalent crosslinking and bilayer permeabilization remains a considerable challenge as crosslinking typically leads to compromised membrane permeability. Herein it is demonstrated how to solve this dilemma by employing a stimuli‐triggered crosslinking strategy with amphiphilic BCPs containing photolabile carbamate‐caged primary amines. Upon self‐assembling into polymersomes, light‐triggered self‐immolative decaging reactions release primary amine moieties and extensive amidation reactions then occur due to suppressed amine p Ka within hydrophobic milieu. This leads to serendipitous vesicle crosslinking and the process is associated with bilayer hydrophobicity‐to‐hydrophilicity transition and membrane permeabilization.
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Cites
Light-triggered self-healing and shape-memory polymers
Habault, D., Zhang, H., & Zhao, Y. (2013) · Chemical Society Reviews · doi:10.1039/c3cs35489j · Cited by 662
Cross-linked polymersome membranes: Vesicles with broadly adjustable properties
Discher, B. M., Bermudez, H., Hammer, D. A., Discher, D. E., Won, Y.-Y., & Bates, F. S. (2002) · The Journal of Physical Chemistry B · doi:10.1021/jp011958z · Cited by 262
Cited by
Photo-responsive polymers: synthesis and applications
Bertrand, O., & Gohy, J.-F. (2017) · Polymer Chemistry · doi:10.1039/c6py01082b · Cited by 364
Polymeric nanostructured materials for biomedical applications
Tang, Z., He, C., Tian, H., Ding, J., Hsiao, B. S., Chu, B., & Chen, X. (2016) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2016.05.005 · Cited by 363
Photoresponsive nanoparticles for drug delivery
Rwei, A. Y., Wang, W., & Kohane, D. S. (2015) · Nano Today · doi:10.1016/j.nantod.2015.06.004 · Cited by 318
Deng, Z., Qian, Y., Yu, Y., Liu, G., Hu, J., Zhang, G., & Liu, S. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b04115 · Cited by 288
Self-citationAntimicrobial polymeric nanoparticles
Lam, S. J., Wong, E. H. H., Boyer, C., & Qiao, G. G. (2018) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2017.07.007 · Cited by 288
Metadata
- Authors
- Wang, X., Liu, G., Hu, J., Zhang, G., & Liu, S.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2014-02-12
- Volume
- 53
- Issue
- 12
- Pages
- 3138-3142
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2136476605
- Cited by
- 225
- References
- 2
- FWCI
- 12.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wang, X., Liu, G., Hu, J., Zhang, G., & Liu, S. (2014). Concurrent Block Copolymer Polymersome Stabilization and Bilayer Permeabilization by Stimuli‐Regulated “Traceless” Crosslinking. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201310589
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