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Direct Surface‐Enhanced Raman Scattering Analysis of DNA Duplexes
Open accessAbstract
The exploration of the genetic information carried by DNA has become a major scientific challenge. Routine DNA analysis, such as PCR, still suffers from important intrinsic limitations. Surface‐enhanced Raman spectroscopy (SERS) has emerged as an outstanding opportunity for the development of DNA analysis, but its application to duplexes (dsDNA) has been largely hampered by reproducibility and/or sensitivity issues. A simple strategy is presented to perform ultrasensitive direct label‐free analysis of unmodified dsDNA with the means of SERS by using positively charged silver colloids. Electrostatic adhesion of DNA promotes nanoparticle aggregation into stable clusters yielding intense and reproducible SERS spectra at nanogram level. As potential applications, we report the quantitative recognition of hybridization events as well as the first examples of SERS recognition of single base mismatches and base methylations (5‐methylated cytosine and N6‐methylated Adenine) in duplexes.
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Cited by
Surface-enhanced Raman spectroscopy: benefits, trade-offs and future developments
Pérez-Jiménez, A. I., Lyu, D., Lu, Z., Liu, G., & Ren, B. (2020) · Chemical Science · doi:10.1039/d0sc00809e · Cited by 912
Fundamental understanding and applications of plasmon-enhanced Raman spectroscopy
Wang, X., Huang, S.-C., Hu, S., Yan, S., & Ren, B. (2020) · Nature Reviews Physics · doi:10.1038/s42254-020-0171-y · Cited by 689
Fan, M., Andrade, G. F. S., & Brolo, A. G. (2020) · Analytica Chimica Acta · doi:10.1016/j.aca.2019.11.049 · Cited by 533
Surface-enhanced Raman spectroscopy: a half-century historical perspective
Yi, J., You, E.-M., Hu, R., Wu, D.-Y., Liu, G.-K., Yang, Z.-L., Zhang, H., Gu, Y., Wang, Y.-H., Wang, X., et al. (2025) · Chemical Society Reviews · doi:10.1039/d4cs00883a · Cited by 382
Self-citationMultiplex in vitro detection using SERS
Laing, S., Gracie, K., & Faulds, K. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00644a · Cited by 361
Metadata
- Authors
- Guerrini, L., Krpetić, Ž., van Lierop, D., Alvarez‐Puebla, R. A., & Graham, D.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2014-11-20
- Volume
- 54
- Issue
- 4
- Pages
- 1144-1148
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2100073570
- Cited by
- 198
- References
- 0
- FWCI
- 5.50
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Guerrini, L., Krpetić, Ž., van Lierop, D., Alvarez‐Puebla, R. A., & Graham, D. (2015). Direct Surface‐Enhanced Raman Scattering Analysis of DNA Duplexes. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201408558
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