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A Smart DNAzyme–MnO 2 Nanosystem for Efficient Gene Silencing
Abstract
DNAzymes hold promise for gene‐silencing therapy, but the lack of sufficient cofactors in the cell cytoplasm, poor membrane permeability, and poor biostability have limited the use of DNAzymes in therapeutics. We report a DNAzyme–MnO 2 nanosystem for gene‐silencing therapy. MnO 2 nanosheets adsorb chlorin e6‐labelled DNAzymes (Ce6), protect them from enzymatic digestion, and efficiently deliver them into cells. The nanosystem can also inhibit 1 O 2 generation by Ce6 in the circulatory system. In the presence of intracellular glutathione (GSH), MnO 2 is reduced to Mn 2+ ions, which serve as cofactors of 10–23 DNAzyme for gene silencing. The release of Ce6 generates 1 O 2 for more efficient photodynamic therapy. The Mn 2+ ions also enhance magnetic resonance contrast, providing GSH‐activated magnetic resonance imaging (MRI) of tumor cells. The integration of fluorescence recovery and MRI activation provides fluorescence/MRI bimodality for monitoring the delivery of DNAzymes.
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Cited by
Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications
Ding, B., Zheng, P., Ma, P., & Lin, J. (2020) · Advanced Materials · doi:10.1002/adma.201905823 · Cited by 521
McConnell, E. M., Cozma, I., Mou, Q., Brennan, J. D., Lu, Y., & Li, Y. (2021) · Chemical Society Reviews · doi:10.1039/d1cs00240f · Cited by 477
Tumor microenvironment-responsive intelligent nanoplatforms for cancer theranostics
Gong, F., Yang, N., Wang, X., Zhao, Q., Chen, Q., Liu, Z., & Cheng, L. (2020) · Nano Today · doi:10.1016/j.nantod.2020.100851 · Cited by 359
Huang, H., Feng, W., & Chen, Y. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01138j · Cited by 285
Zhu, Q., Chen, X., Xu, X., Zhang, Y., Zhang, C., & Mo, R. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201707371 · Cited by 105
Metadata
- Authors
- Fan, H., Zhao, Z., Yan, G., Zhang, X., Yang, C., Meng, H., Chen, Z., Liu, H., & Tan, W.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2015-02-26
- Volume
- 54
- Issue
- 16
- Pages
- 4801-4805
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2135284562
- Cited by
- 328
- References
- 0
- FWCI
- 14.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fan, H., Zhao, Z., Yan, G., Zhang, X., Yang, C., Meng, H., Chen, Z., Liu, H., & Tan, W. (2015). A Smart DNAzyme–MnO 2 Nanosystem for Efficient Gene Silencing. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201411417
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