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Photoinduced Copper‐Catalyzed Regioselective Synthesis of Indoles: Three‐Component Coupling of Arylamines, Terminal Alkynes, and Quinones

Sagadevan, Arunachalam, Ragupathi, Ayyakkannu, Hwang, Kuo Chu·2015·Angewandte Chemie International Edition

Abstract

The first successful example of a visible‐light‐induced copper‐catalyzed process for CH annulation of arylamines with terminal alkynes and benzoquinone is described. This three‐component reaction allows use of a variety of commercial terminal alkynes as coupling partners for the one‐step regioselective synthesis of functionalized indoles. Moreover, the current process represents a sustainable and atom‐economical approach for the preparation of complex indoles from easily accessible starting materials under visible‐light irradiation, without the need for expensive metals and harsh reaction conditions.

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Metadata

Authors
Sagadevan, A., Ragupathi, A., & Hwang, K. C.
Venue
Angewandte Chemie International Edition
Publisher
Wiley
Published
2015-09-04
Volume
54
Issue
47
Pages
13896-13901
ISSN
  • 1433-7851 (ISSN-L)
  • 1521-3773
OpenAlex
W2131739694
Cited by
158
References
1
FWCI
6.74
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Photoinduced Copper‐Catalyzed Regioselective Synthesis of Indoles: Three‐Component Coupling of Arylamines, Terminal Alkynes, and Quinones. https://app.cochat.ai/papers/10.1002/anie.201506579
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Sagadevan, A., Ragupathi, A., & Hwang, K. C. (2015). Photoinduced Copper‐Catalyzed Regioselective Synthesis of Indoles: Three‐Component Coupling of Arylamines, Terminal Alkynes, and Quinones. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201506579

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