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Directed Evolution: Bringing New Chemistry to Life
Open accessAbstract
Tailor-made: Discussed herein is the ability to adapt biology's mechanisms for innovation and optimization to solving problems in chemistry and engineering. The evolution of nature's enzymes can lead to the discovery of new reactivity, transformations not known in biology, and reactivity inaccessible by small-molecule catalysts.
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Cited by
Nikel, P. I., & de Lorenzo, V. (2018) · Metabolic Engineering · doi:10.1016/j.ymben.2018.05.005 · Cited by 480
Bacterial Candidates for Colonization and Degradation of Marine Plastic Debris
Roager, L., & Sonnenschein, E. C. (2019) · Environmental Science & Technology · doi:10.1021/acs.est.9b02212 · Cited by 305
Bioeconomy for sustainable development
Aguilar, A., Twardowski, T., & Wohlgemuth, R. (2019) · Biotechnology Journal · doi:10.1002/biot.201800638 · Cited by 206
Unifying the known and unknown microbial coding sequence space
Vanni, C., Schechter, M. S., Acinas, S. G., Barberán, A., Buttigieg, P. L., Casamayor, E. O., Delmont, T. O., Duarte, C. M., Eren, A. M., Finn, R. D., et al. (2022) · eLife · doi:10.7554/elife.67667 · Cited by 134
Machine learning modeling of family wide enzyme-substrate specificity screens
Goldman, S., Das, R., Yang, K. K., & Coley, C. W. (2022) · PLOS Computational Biology · doi:10.1371/journal.pcbi.1009853 · Cited by 120
Metadata
- Authors
- Arnold, F. H.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2017-11-28
- Volume
- 57
- Issue
- 16
- Pages
- 4143-4148
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2767044445
- Cited by
- 1,144
- References
- 0
- FWCI
- 31.06
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
