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Cited by 243

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Reevaluating Protein Photoluminescence: Remarkable Visible Luminescence upon Concentration and Insight into the Emission Mechanism

Wang, Qian, Dou, Xueyu, Chen, Xiaohong, Zhao, Zihao, Wang, Shuang, Wang, Yunzhong, Sui, Kunyan, Tan, Yeqiang, Gong, Yongyang, Zhang, Yongming, Yuan, Wang Zhang·2019·Angewandte Chemie International Edition

Abstract

It is a textbook knowledge that protein photoluminescence stems from the three aromatic amino acid residues of tryptophan(Trp), tyrosine (Tyr), and phenylalanine (Phe), with predominant contributions from Trp. Recently, inspired by the intrinsic emission of nonaromatic amino acids and poly(amino acids) in concentrated solutions and solids, we revisited protein light emission using bovine serum albumin (BSA) as a model. BSA is virtually nonemissive in dilute solutions (≤0.1 mg mL−1), but highly luminescent upon concentration or aggregation, showing unique concentration‐enhanced emission and aggregation‐induced emission (AIE) characteristics. Notably, apart from well‐documented UV luminescence, bright blue emission is clearly observed. Furthermore, persistent room‐temperature phosphorescence (p‐RTP) is achieved even in the amorphous solids under ambient conditions. This visible emission can be rationalized by the clustering‐triggered emission (CTE) mechanism. These findings not only provide an in‐depth understanding of the emissive properties of proteins, but also hold strong implications for further elucidating the basis of tissue autofluorescence.

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Metadata

Authors
Wang, Q., Dou, X., Chen, X., Zhao, Z., Wang, S., Wang, Y., Sui, K., Tan, Y., Gong, Y., Zhang, Y., & Yuan, W. Z.
Venue
Angewandte Chemie International Edition
Publisher
Wiley
Published
2019-07-26
Volume
58
Issue
36
Pages
12667-12673
ISSN
  • 1433-7851 (ISSN-L)
  • 1521-3773
OpenAlex
W2967258782
Cited by
243
References
1
FWCI
9.99
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Reevaluating Protein Photoluminescence: Remarkable Visible Luminescence upon Concentration and Insight into the Emission Mechanism. https://app.cochat.ai/papers/10.1002/anie.201906226
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Wang, Q., Dou, X., Chen, X., Zhao, Z., Wang, S., Wang, Y., Sui, K., Tan, Y., Gong, Y., Zhang, Y., & Yuan, W. Z. (2019). Reevaluating Protein Photoluminescence: Remarkable Visible Luminescence upon Concentration and Insight into the Emission Mechanism. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.201906226

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