An AIE‐Active Conjugated Polymer with High ROS‐Generation Ability and Biocompatibility for Efficient Photodynamic Therapy of Bacterial Infections
Abstract
New, biocompatible materials with favorable antibacterial activity are highly desirable. In this work, we develop a unique conjugated polymer featuring aggregation‐induced emission (AIE) for reliable bacterial eradication. Thanks to the AIE and donor‐π‐acceptor structure, this polymer shows a high reactive oxygen species (ROS)‐generation ability compared to a low‐mass model compound and the common photosensitizer Chlorin E6. Moreover, the selective binding of pathogenic microorganisms over mammalian cells was found, demonstrating its biocompatibility. The effective growth inhibition of bacteria upon polymer treatment under light irradiation was validated in vitro and in vivo. Notably, the recovery from infection after treatment with our polymer is faster than that with cefalotin. Thus, this polymer holds great promise in fighting against bacteria‐related infections in practical applications.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The citation lists haven’t been fetched yet
References 24 · Cited by 265
- Authors
- Zhou, T., Hu, R., Wang, L., Qiu, Y., Zhang, G., Deng, Q., Zhang, H., Yin, P., Situ, B., Zhan, C., Qin, A., & Tang, B. Z.
- Affiliations
- State Key Laboratory of Luminescent Materials and Devices (CN)
- Department of Medical Research General Hospital of Southern Theater Command, PLA Guangzhou 510010 China
- State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates Center for Aggregation-Induced Emission South China University of Technology Guangzhou 510640 China
- Nanfang Hospital (CN)
- Animal Experiment Centery General Hospital of Southern Theater Command, PLA Guangzhou 510010 China
- Hong Kong University of Science and Technology (HK)
- Corresponding author
- Qin, Anjun
- Tang, Ben Zhong
- ORCID
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2020-03-11
- Volume
- 59
- Issue
- 25
- Pages
- 9952-9956
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W3004451834
- Cited by
- 265
- References
- 24
- Citations by year
- 2026: 13 · 2025: 27 · 2024: 50 · 2023: 50 · 2022: 63 · 2021: 49 · 2020: 13
- FWCI
- 24.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- Funders
- National Natural Science Foundation of China (21788102, 21525417, 21907034 and 51620105009)
- Natural Science Foundation of Guangdong Province (2019B030301003, 2018A030313763 and 2016A030312002)
- Fundamental Research Funds for the Central Universities (D2191530)
- Innovation and Technology Commission (ITC-CNERC14S01)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Keywords
- aggregation-induced emission, conjugated polymers, photodynamic therapy, reactive oxygen species generation, antibacterial activity, bacterial infection, donor-π-acceptor structure, biocompatibility, photosensitizers, chlorin e6
- MeSH terms
- Animals, Bacteria, Bacterial Infections, Biocompatible Materials, Cells, Cultured, Chlorophyllides, HeLa Cells, Humans, Microbial Sensitivity Tests, Photochemotherapy, Polymers, Porphyrins, Photosensitizing Agents, Reactive Oxygen Species
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
