Molecular design of highly efficient heavy-atom-free triplet BODIPY derivatives for photodynamic therapy and bioimaging
Abstract
Abstract Novel BODIPY photosensitizers were developed for imaging‐guided photodynamic therapy. The introduction of a strong electron donor to the BODIPY core through a phenyl linker combined with the twisted arrangement between the donor and the BODIPY acceptor is essential for reducing the energy gap between the lowest singlet excited state and the lowest triplet state (Δ E ST ), leading to a significant enhancement in the intersystem crossing (ISC) of the BODIPYs. Remarkably, the BDP‐5 with the smallest Δ E ST (ca. 0.44 eV) exhibited excellent singlet oxygen generation capabilities in both organic and aqueous solutions. BDP‐5 also displayed bright emission in the far‐red/near‐infrared region in the condensed states. More importantly, both in vitro and in vivo studies demonstrated that BDP‐5 NPs displayed a high potential for photodynamic cancer therapy and bioimaging.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The citation lists haven’t been fetched yet
References 38 · Cited by 326
- Authors
- Nguyen, V., Yim, Y., Kim, S., Ryu, B., Swamy, K. M. K., Kim, G., Kwon, N., Kim, C., Park, S., & Yoon, J.
- Affiliations
- Ewha Womans University (KR)
- Korea University (KR)
- Seoul National University (KR)
- Konkuk University (KR)
- Corresponding author
- Kim, C‐Yoon
- Park, Sungnam
- Yoon, Juyoung
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2020-03-24
- Volume
- 59
- Issue
- 23
- Pages
- 8957-8962
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W3009394325
- Cited by
- 326
- References
- 38
- Citations by year
- 2026: 36 · 2025: 48 · 2024: 70 · 2023: 45 · 2022: 55 · 2021: 50 · 2020: 22
- FWCI
- 16.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Research Foundation of Korea (2012R1A3A2048814, 2019R1A6A1A11044070)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- BODIPY photosensitizers, triplet state, intersystem crossing, singlet oxygen generation, heavy-atom-free photosensitizers, phenyl linker, energy gap reduction, near-infrared emission, photodynamic cancer therapy, bioimaging
- MeSH terms
- Boron Compounds, Humans, Photochemotherapy, Drug Design, Photosensitizing Agents, Cell Line, Tumor, Molecular Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
