Stretchable Electrochemical Sensors for Cell and Tissue Detection
Abstract
Electrochemical sensing based on conventional rigid electrodes has great restrictions for characterizing biomolecules in deformed cells or soft tissues. The recent emergence of stretchable sensors allows electrodes to conformally contact to curved surfaces and perfectly comply with the deformation of living cells and tissues. This provides a powerful strategy to monitor biomolecules from mechanically deformed cells, tissues, and organisms in real time, and opens up new opportunities to explore the mechanotransduction process. In this minireview, we first summarize the fabrication of stretchable electrodes with emphasis on the nanomaterial-enabled strategies. We then describe representative applications of stretchable sensors in the real-time monitoring of mechanically sensitive cells and tissues. Finally, we present the future possibilities and challenges of stretchable electrochemical sensing in cell, tissue, and in vivo detection.
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PFASs are widely used in medical device manufacturing, including coatings for surgical tools and medical devices for properties such as thermal stability and hydrophobicity.
“PFASs are widely used in medical device manufacturing, including coatings for surgical tools and medical devices for properties such as thermal stability and hydrophobicity [58].”
From Industrial Applications, Environmental Fate, Human Exposure, and Health Effects of PFAS (2025) · cites this paper as [58]
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References 100 · Cited by 105
- Authors
- Liu, Y., & Huang, W.
- Affiliations
- Wuhan University (CN)
- Corresponding author
- Huang, Wei‐Hua
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2020-11-26
- Volume
- 60
- Issue
- 6
- Pages
- 2757-2767
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W3038428121
- Cited by
- 105
- References
- 100
- Citations by year
- 2026: 9 · 2025: 8 · 2024: 23 · 2023: 25 · 2022: 17 · 2021: 20 · 2020: 3
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Angewandte Chemie International Edition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (21725504, 21675121, 21804101)
- Innovative Research Group Project of the National Natural Science Foundation of China (21721005)
- Postdoctoral Research Foundation of China (2017M620329, 2018T110790)
- Fundamental Research Funds for the Central Universities (2042019kf0274)
- Topics
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Physical Sciences › Engineering › Biomedical Engineering › Advanced Sensor and Energy Harvesting Materials
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced biosensing and bioanalysis techniques
- Keywords
- stretchable electrodes, mechanotransduction, cell deformation, in vivo sensing, flexible electronics
- MeSH terms
- Electrodes, Humans, Nitric Oxide, Polymers, Umbilical Veins, Biosensing Techniques, Mechanotransduction, Cellular, Nanostructures, Electrochemical Techniques, Human Umbilical Vein Endothelial Cells
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