The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A Mitochondrion‐Localized Two‐Photon Photosensitizer Generating Carbon Radicals Against Hypoxic Tumors
Abstract
The efficacy of photodynamic therapy is typically reliant on the local concentration and diffusion of oxygen. Due to the hypoxic microenvironment found in solid tumors, oxygen‐independent photosensitizers are in great demand for cancer therapy. We herein report an iridium(III) anthraquinone complex as a mitochondrion‐localized carbon‐radical initiator. Its emission is turned on under hypoxic conditions after reduction by reductase. Furthermore, its two‐photon excitation properties (λex=730 nm) are highly desirable for imaging. Upon irradiation, the reduced form of the complex generates carbon radicals, leading to a loss of mitochondrial membrane potential and cell death (IC 50light=2.1 μ m, IC 50dark=58.2 μ m, PI=27.7). The efficacy of the complex as a PDT agent was also demonstrated under hypoxic conditions in vivo. To the best of our knowledge, it is the first metal‐complex‐based theranostic agent which can generate carbon radicals for oxygen‐independent two‐photon photodynamic therapy.
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Cites
Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy
Mehta, G., Hsiao, A. Y., Ingram, M., Luker, G. D., & Takayama, S. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.04.045 · Cited by 1,172
Detection and Characterization of Tumor Hypoxia Using pO 2 Histography
Vaupel, P., Höckel, M., & Mayer, A. (2007) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1628 · Cited by 728
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Lee, L. C.-C., & Lo, K. K.-W. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c03437 · Cited by 279
Mitochondria targeted fluorogenic theranostic agents for cancer therapy
Singh, H., Sareen, D., George, J. M., Bhardwaj, V., Rha, H., Lee, S. J., Sharma, S., Sharma, A., & Kim, J. S. (2022) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2021.214283 · Cited by 72
Metadata
- Authors
- Kuang, S., Sun, L., Zhang, X., Liao, X., Rees, T. W., Zeng, L., Chen, Y., Zhang, X., Ji, L., & Chao, H.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2020-09-03
- Volume
- 59
- Issue
- 46
- Pages
- 20697-20703
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W3046886685
- Cited by
- 161
- References
- 2
- FWCI
- 11.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kuang, S., Sun, L., Zhang, X., Liao, X., Rees, T. W., Zeng, L., Chen, Y., Zhang, X., Ji, L., & Chao, H. (2020). A Mitochondrion‐Localized Two‐Photon Photosensitizer Generating Carbon Radicals Against Hypoxic Tumors. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.202009888
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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