Control of Crystallinity and Stereocomplexation of Synthetic Carbohydrate Polymers from d‐ and l‐Xylose
Open accessAbstract
Manipulating the stereochemistry of polymers is a powerful method to alter their physical properties. Despite the chirality of monosaccharides, reports on the impact of stereochemistry in natural polysaccharides and synthetic carbohydrate polymers remain absent. Herein, we report the cocrystallisation of regio‐ and stereoregular polyethers derived from d‐ and l‐xylose, leading to enhanced thermal properties compared to the enantiopure polymers. To the best of our knowledge, this is the first example of a stereocomplex between carbohydrate polymers of opposite chirality. In contrast, atactic polymers obtained from a racemic mixture of monomers are amorphous. We also show that the polymer hydroxyl groups are amenable to post‐polymerisation functionalization. These strategies afford a family of carbohydrate polyethers, the physical and chemical properties of which can both be controlled, and which opens new possibilities for polysaccharide mimics in biomedical applications or as advanced materials.
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The mechanical properties of PLA face limitations such as high rigidity or unsuited degradation time, which are necessary to overcome to make the bioplastic widely applicable.
“However, the mechanical properties of PLA face some limitations like a high rigidity or unsuited degradation time, which are necessary to overcome in order to make the bioplastic widely applicable. [7]”
From Master of Chaos and Order: Opposite Microstructures of PCL‐<i>co</i>‐PGA‐<i>co</i>‐PLA Accessible by a Single Catalyst** (2022) · cites this paper as [7]
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- Authors
- McGuire, T. M., Bowles, J., Deane, E., Farrar, E. H. E., Grayson, M. N., & Buchard, A.
- Affiliations
- University of Bath (GB)
- Corresponding author
- Buchard, Antoine
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2021-01-07
- Volume
- 60
- Issue
- 9
- Pages
- 4524-4528
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- PMC
- PMC7986207
- OpenAlex
- W3107454980
- Cited by
- 55
- References
- 40
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 12 · 2023: 11 · 2022: 11 · 2021: 5
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Angewandte Chemie International Edition (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Royal Society (RG/150538, UF/160021)
- Engineering and Physical Sciences Research Council (DTP Studenship, EP/N022793/1)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Physical Sciences › Materials Science › Polymers and Plastics › Polymer crystallization and properties
- Keywords
- stereocomplexation, carbohydrate polymers, xylose, D-xylose, L-xylose, polyethers, co-crystallization, tacticity, crystallinity, thermal properties, chirality
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