The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Acetylxylan‐pheophorbide‐a nanoparticles designed for tumor‐targeted photodynamic therapy
Abstract
Abstract The poor solubility of most photosensitizers (PS) hampers their practical use as clinical agents. Conjugation of PS with water‐soluble nanoparticles has been often used to bypass this hurdle. We describe in this study the extraction of glucuronoacetylxylan from chestnut sawdust, the hemisynthesis of pheophorbide‐a (Pha) and its covalent attachment to xylan. The resulting conjugates (xyl‐Pha) spontaneously form water‐soluble spherical nanoparticles (xyl‐Pha NPs) ranging between 100 and 250 nm in diameter. Assayed against the HT‐29 colorectal cancer cell line, xyl‐Pha NPs exhibited a dose‐dependent phototoxicity only when irradiated with red light.
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“After red light irradiation (630–660 nm at 75 J/cm2), the xyl-Pha nanoparticles showed cytotoxic activity against HT-29 human colorectal cancer cells.”
From Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp. (2023) · cites this paper as [139]
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Cited by
Sorted by citations
Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp.
Abreu, A. P., Martins, R., & Nunes, J. (2023) · Bioengineering · doi:10.3390/bioengineering10080955 · Cited by 119
Metadata
- Authors
- Bouramtane, S., Bretin, L., Pinon, A., Leger, D., Liagre, B., Perez, D. D. S., Launay, Y., Brégier, F., Sol, V., & Chaleix, V.
- Affiliations
- PEIRENE (FR)
- Institut Technologique Forêt Cellulose Bois-Construction Ameublement (FR)
- Centre Européen de la Céramique (FR)
- Corresponding author
- Chaleix, Vincent
- ORCID
- Venue
- Journal of Applied Polymer Science
- Publisher
- Wiley
- Published
- 2021-04-02
- Volume
- 138
- Issue
- 32
- ISSN
- 0021-8995 (ISSN-L)
- 1097-4628
- OpenAlex
- W3142400940
- Cited by
- 20
- References
- 29
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 1
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Polymer Science (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- pheophorbide a, xylan, photosensitizers, photodynamic therapy, nanoparticle self-assembly, hemisynthesis, covalent conjugation, water-soluble nanoparticles, colorectal cancer, HT-29 cells, red light irradiation, phototoxicity
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