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Glomerular number and size in relation to age, kidney weight, and body surface in normal man
Abstract
The number and size of glomeruli in normal, mature human kidneys were estimated by a direct and unbiased stereological method, the fractionator. The number was 617,000 on average, and the mean size 6.0 M μm 3. Both glomerular number and size showed significant negative correlation to age and significant positive correlation to kidney weight. Apparently, humans loose glomeruli with age. Body surface area correlated positively to kidney weight and total glomerular volume but not to number of glomeruli. Body surface area correlates significantly with metabolic rate (Robertson and Reid, Lancet, 1: 940–943, 1952). Thus, intraspecies adaptation of kidney filtration capacity to the metabolic demand is performed by changing the size of glomeruli, i. e., the number of glomeruli in individuals of a given species is independent of the metabolic rate.
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Cited by
Structural and Functional Changes With the Aging Kidney
Denic, A., Glassock, R. J., & Rule, A. D. (2016) · Advances in Chronic Kidney Disease · doi:10.1053/j.ackd.2015.08.004 · Cited by 819
Nguyen, H. T., Benson, C. B., Bromley, B., Campbell, J. B., Chow, J., Coleman, B., Cooper, C., Crino, J., Darge, K., Anthony Herndon, C. D., et al. (2014) · Journal of Pediatric Urology · doi:10.1016/j.jpurol.2014.10.002 · Cited by 561
Luyckx, V. A., Bertram, J. F., Brenner, B. M., Fall, C., Hoy, W. E., Ozanne, S. E., & Vikse, B. E. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60311-6 · Cited by 554
Molecular and physiological manifestations and measurement of aging in humans
Khan, S. S., Singer, B. D., & Vaughan, D. E. (2017) · Aging Cell · doi:10.1111/acel.12601 · Cited by 530
Renal Aging: Causes and Consequences
O’Sullivan, E. D., Hughes, J., & Ferenbach, D. A. (2017) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015121308 · Cited by 484
Metadata
- Authors
- Nyengaard, J. R., & Bendtsen, T. F.
- Venue
- The Anatomical Record
- Publisher
- Wiley
- Published
- 1992-02
- Volume
- 232
- Issue
- 2
- Pages
- 194-201
- ISSN
- 0003-276X (ISSN-L)
- 1097-0185
- OpenAlex
- W2027171099
- Cited by
- 879
- References
- 0
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Glomerular number and size in relation to age, kidney weight, and body surface in normal man. https://app.cochat.ai/papers/10.1002/ar.1092320205
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- Nyengaard, J. R., & Bendtsen, T. F. (1992). Glomerular number and size in relation to age, kidney weight, and body surface in normal man. The Anatomical Record. https://doi.org/10.1002/ar.1092320205
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
