Mitochondrial Division in Rat Cardiomyocytes: An Electron Microscope Study
Open accessAbstract
In cardiomyocytes of rats, two distinct mitochondrial division processes are in operation. The predominant process involves extension of a single crista until it spans the full width of a mitochondrion. Ingrowth of the outer membrane ultimately results in scission. The second division process involves “pinching,” in which narrowing of the organelle at specific surface locations leads to its attenuation. When limiting membranes from opposite sides meet, mitochondrial fission ensues. When pinching is the operative mode, elements of sarcoplasmic reticulum always are associated with the membrane constrictions. The nuclear control mechanisms that determine which modality of mitochondrial division will prevail are unknown. Anat Rec, 2012. © 2012 Wiley Periodicals, Inc.
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In the absence of DRP1 or OMM constriction, IMM division still occurs, indicating the presence of an inner membrane fission machinery independent of DRP1.
“In the absence of DRP1 or OMM constriction, the IMM division still occurs, indicating the presence of an inner membrane fission machinery independent of DRP1 [100, 101].”
From The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass (2021) · cites this paper as [101]
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References 40 · Cited by 51
- Authors
- Fujioka, H., Tandler, B., & Hoppel, C. L.
- Affiliations
- Case Western Reserve University (US)
- Corresponding author
- Fujioka, Hisashi
- Venue
- The Anatomical Record
- Publisher
- Wiley
- Published
- 2012-07-02
- Volume
- 295
- Issue
- 9
- Pages
- 1455-1461
- ISSN
- 1932-8486 (ISSN-L)
- 1932-8494
- PMC
- PMC3744323
- OpenAlex
- W2064041490
- Cited by
- 51
- References
- 40
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 1 · 2018: 8 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Anatomical Record (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Case Western Reserve University
- Kenan Institute for Engineering, Technology and Science
- National Institute on Aging (P01AG015885)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- mitochondrial division, mitochondrial fission, cardiomyocytes, pinching, sarcoplasmic reticulum, rat heart
- MeSH terms
- Animals, Cell Division, Microscopy, Electron, Mitochondria, Heart, Rats, Inbred BN, Rats, Inbred F344, Myocytes, Cardiac, Rats
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