The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The association of body mass index and osteoarthritis of the knee joint: An examination of genetic and environmental influences
Abstract
Objective: To examine the genetic and environmental influences on the known association between body mass index (BMI) and knee osteoarthritis (OA), using adult twin data. Methods: Bilateral knee radiographs were obtained from 785 pairs of healthy female twins (mean age 54.5 ± 7.8 years) from the St. Thomas' Hospital Adult Twin Registry (261 monozygotic [MZ] and 524 dizygotic [DZ] twin pairs). Tibiofemoral knee OA was graded according to the Kellgren and Lawrence (K/L) scoring system on an ordinal scale of 0–4. Presence of knee OA was defined as a K/L grade of ≥2 on either side of the knee joint. Body weight and height were measured and the subjects were stratified into quartiles of BMI. Cross‐trait cross‐twin association of BMI and knee OA was assessed by logistic regression, to assess whether genetic or environmental influences explain the BMI–knee OA link. The genetic (heritability) and environmental contributions to each of the measures were estimated using path modeling. Results: A strong association was found between high BMI and the presence of knee OA (odds ratio 3.90 for highest versus lowest quartile of BMI; P = 0.0001). The heritability of knee OA was 50.4% (95% confidence interval [95% CI] 34–62%) and that of BMI was 55.7% (95% CI 35–72%). However, cross‐trait cross‐twin associations were not significantly different from unity in either the MZ or DZ twin pairs, indicating that shared genetic influences were unlikely to explain the association. Path modeling showed that the model containing additive genetic factors, common environmental factors, and unique environmental factors had the best fit to the data overall. The shared genetic path between BMI and knee OA could be dropped without deterioration in the fit of the model. Conclusion: The strong association between high BMI and knee OA is not likely to be mediated by shared genetic factors. The results imply that environmental modification of BMI can influence knee OA.
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Citations
Cites
Obesity and Knee Osteoarthritis: The Framingham Study
Felson, D. T., Anderson, J. J., Naimark, A., Walker, A. M., & Meenan, R. F. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-109-1-18 · Cited by 1,080
Andrew, T., Hart, D. J., Snieder, H., de Lange, M., Spector, T. D., & MacGregor, A. J. (2001) · Twin Research · doi:10.1375/1369052012803 · Cited by 440
Self-citation
Cited by
Obesity and Perioperative Morbidity in Total Hip and Total Knee Arthroplasty Patients
Namba, R. S., Paxton, L., Fithian, D. C., & Stone, M. L. (2005) · The Journal of Arthroplasty · doi:10.1016/j.arth.2005.04.023 · Cited by 486
Reijman, M., Pols, H. A. P., Bergink, A. P., Hazes, J. M. W., Belo, J. N., Lievense, A. M., & Bierma-Zeinstra, S. M. A. (2007) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.053538 · Cited by 470
Belmont, P. J., Goodman, G. P., Waterman, B. R., Bader, J. O., & Schoenfeld, A. J. (2014) · Journal of Bone and Joint Surgery · doi:10.2106/jbjs.m.00018 · Cited by 438
McLawhorn, A. S., Levack, A. E., Lee, Y.-Y., Ge, Y., Do, H., & Dodwell, E. R. (2018) · The Journal of Arthroplasty · doi:10.1016/j.arth.2017.11.056 · Cited by 93
Metadata
- Authors
- Manek, N. J., Hart, D., Spector, T. D., & MacGregor, A. J.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 2003-04
- Volume
- 48
- Issue
- 4
- Pages
- 1024-1029
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2050889305
- Cited by
- 209
- References
- 2
- FWCI
- 8.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Manek, N. J., Hart, D., Spector, T. D., & MacGregor, A. J. (2003). The association of body mass index and osteoarthritis of the knee joint: An examination of genetic and environmental influences. Arthritis & Rheumatism. https://doi.org/10.1002/art.10884
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
