The DOI matches its Crossref record.
Diversity of antinuclear antibodies in progressive systemic sclerosis
Abstract
Antinuclear antibodies wer demonstrated in the sera of 43 of 45 (96%) patients with progressive systemic sclerosis (22 of 24 with diffuse scleroderma and 21 of 21 with the CREST syndrome variant). This high percentage of positive reactions resulted from the use of a tissue culture substrate (Hep‐2) to detect antinuclear antibodies by the indirect immunofluorescent method. Patterns of nuclear staining included diffuse fine speckles, large coarse speckles, nucleolar and centromere staining. When organ sections such as mouse kidney were used as substrate for the detection of antinuclear antibodies, nucleolar staining and centromere staining were the two patterns most frequently overlooked. Three types of antibodies appeared to be highly specific for scleroderma: antibody to Sc1‐70 antigen, antibody to centromere, and antinucleolar antibody. The anti‐centromere antibody appeared to be highly selective for the CREST variant of progressive systemic sclerosis.
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Cited by
Mimori, T., Akizuki, M., Yamagata, H., Inada, S., Yoshida, S., & Homma, M. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110295 · Cited by 448
Nakamura, M., Kondo, H., Mori, T., Komori, A., Matsuyama, M., Ito, M., Takii, Y., Koyabu, M., Yokoyama, T., Migita, K., et al. (2007) · Hepatology · doi:10.1002/hep.21472 · Cited by 365
On Scleroderma: Mast Cells, Endothelial Cells, and Fibroblasts
Claman, H. N. (1989) · JAMA · doi:10.1001/jama.1989.03430090068035 · Cited by 112
Bunn, C., & Mcmorrow, M. (2008) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.1995.tb06646.x · Cited by 8
Metadata
- Authors
- Tan, E. M., Rodnan, G. P., Garcia, I., Moroi, Y., Fritzler, M. J., & Peebles, C.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 1980-06
- Volume
- 23
- Issue
- 6
- Pages
- 617-625
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2002027999
- Cited by
- 524
- References
- 0
- FWCI
- 22.37
- Type
- journal article
- Language
- en
- Open access
- closed
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- Tan, E. M., Rodnan, G. P., Garcia, I., Moroi, Y., Fritzler, M. J., & Peebles, C. (1980). Diversity of antinuclear antibodies in progressive systemic sclerosis. Arthritis & Rheumatism. https://doi.org/10.1002/art.1780230602
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