Rheumatic fever‐associated B cell alloantigens as identified by monoclonal antibodies
Abstract
Mice immunized with B lymphocytes obtained from patients who had had well-documented rheumatic fever in the past yielded 2 monoclonal antibodies, termed 83S19.23 and 256S10, which identified certain alloantigens present on the B cells of these patients. The frequency of the B cell marker detected by clone 83S19.23 in rheumatic fever patients was found to be 59%, 77%, and 74% in India, New Mexico, and New York, respectively. Monoclonal antibody 256S10 identified 75% of those rheumatic fever patients who were nonreactive to clone 83S19.23. Thus, the 2 antibodies identify approximately 92% of all rheumatic fever patients and suggest the presence of a diallelic genetic marker for susceptibility to rheumatic fever.
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A high frequency of in vitro elevated D8/17 binding to B lymphocytes has been found as a susceptibility marker for developing ARF more than PSRA.
“A high frequency of in vitro elevated D8/17 binding to B lymphocytes has been found as a susceptibility marker for developing ARF more than PSRA [7, 8, 24].”
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Jansen, T. L. T. A. (2009) · International Journal of Rheumatology · doi:10.1155/2009/286951
“A high frequency of in vitro elevated D8/17 binding to B lymphocytes has been found as a susceptibility marker for developing ARF more than PSRA [7, 8, 24].”
Background
- Authors
- Zabriskie, J. B., Lavenchy, D., Williams, R. C., Fu, S. M., Yeadon, C. A., Fotino, M., & Braun, D. G.
- Affiliations
- Rockefeller University (US)
- University of New Mexico (US)
- Oklahoma Medical Research Foundation (US)
- Royal Victoria Hospital (CA)
- New York Blood Center (US)
- Corresponding author
- Zabriskie, J. B.
- ORCID
- Fu, S. M.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 1985-09
- Volume
- 28
- Issue
- 9
- Pages
- 1047-1051
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2030195453
- Cited by
- 110
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2020: 1 · 2019: 3 · 2018: 1 · 2016: 3 · 2015: 2 · 2013: 3 · 2012: 2
- FWCI
- 7.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Arthritis & Rheumatism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI 14361)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Streptococcal Infections and Treatments
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
- Keywords
- rheumatic fever, B-cell alloantigens, monoclonal antibodies, B cells, serological diagnosis
- MeSH terms
- Antibodies, Monoclonal, Antibody Specificity, B-Lymphocytes, Clone Cells, Humans, Hybridomas, India, Isoantigens, Rheumatic Fever, United States
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