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Analysis of improvement in individual rheumatoid arthritis patients treated with disease‐modifying antirheumatic drugs, based on the findings in patients treated with placebo
Abstract
A composite index for estimating improvement in individual rheumatoid arthritis (RA) patients during trials of slow‐acting, disease‐modifying antirheumatic drugs (DMARDs) was developed by analyzing the responses of 130 placebo‐treated participants in Cooperative Systematic Studies of Rheumatic Diseases studies. If responses in 4 of 6 selected measures were required for improvement (by ⩾20% for morning stiffness, Westergren erythrocyte sedimentation rate, joint pain/tenderness score, and joint swelling score, and by ⩾2 grades on a 5‐grade scale, or from grade 2 to grade 1 for patient's and physician's overall assessments of current disease severity), few placebo‐treated patients qualified as improved, whereas significantly more DMARD‐treated patients demonstrated improvement. The proposed index appears to be useful in estimating the probability that an RA patient will improve if taking a placebo during a DMARD trial, and may be a useful tool for analysis of DMARD studies.
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Cited by
Elliott, M. J., Maini, R. N., Feldmann, M., Kalden, J. R., Antoni, C., Smolen, J. S., Leeb, B., Breedveld, F. C., Macfarlane, J. D., Bijl, J. A., et al. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90628-9 · Cited by 1,682
Etanercept Therapy in Rheumatoid Arthritis: A Randomized, Controlled Trial
Moreland, L. W., Schiff, M. H., Baumgartner, S. W., Tindall, E. A., Fleischmann, R. M., Bulpitt, K. J., Weaver, A. L., Keystone, E. C., Furst, D. E., Mease, P. J., et al. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-6-199903160-00004 · Cited by 1,379
Gamma linolenic acid treatment of rheumatoid arthritis. A randomized, placebo-controlled trial
Zurier, R. B., Rossetti, R. G., Jacobson, E. W., Demarco, D. M., Liu, N. Y., Temming, J. E., White, B. M., & Laposata, M. (1996) · Arthritis & Rheumatism · doi:10.1002/art.1780391106 · Cited by 217
Blocking the effects of IL-1 in rheumatoid arthritis protects bone and cartilage.
Abramson, S. B. (2002) · Rheumatology · doi:10.1093/rheumatology/41.9.972 · Cited by 217
The Definition and Measurement of Disease Modification in Inflammatory Rheumatic Diseases
Aletaha, D., & Smolen, J. S. (2006) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2005.09.005 · Cited by 152
Metadata
- Authors
- Paulus, H. E., Egger, M. J., Ward, J. R., & James Williams, H.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 1990-04
- Volume
- 33
- Issue
- 4
- Pages
- 477-484
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2048462515
- Cited by
- 285
- References
- 0
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Analysis of improvement in individual rheumatoid arthritis patients treated with disease‐modifying antirheumatic drugs, based on the findings in patients treated with placebo. https://app.cochat.ai/papers/10.1002/art.1780330403
- The paper
- Paulus, H. E., Egger, M. J., Ward, J. R., & James Williams, H. (1990). Analysis of improvement in individual rheumatoid arthritis patients treated with disease‐modifying antirheumatic drugs, based on the findings in patients treated with placebo. Arthritis & Rheumatism. https://doi.org/10.1002/art.1780330403
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