Androgen replacement therapy in male patients with rheumatoid arthritis
Abstract
A hypogonadic condition characterized by low serum testosterone levels has been identified in male patients with rheumatoid arthritis (RA). Seven men with active RA were treated daily for 6 months with oral testosterone undecanoate plus a nonsteroidal antiinflammatory drug in an attempt to evaluate the immunologic response, the overall clinical response, and the sex hormone response to such replacement therapy. At the end of the 6 months, there was a significant increase in serum testosterone levels (P < 0.05), an increase in the number of CD8+ T cells, and a decrease in the CD4+ :CD8+ T cell ratio. The IgM rheumatoid factor concentration decreased significantly (P < 0.05). There was a concurrent significant reduction in the number of affected joints (P < 0.05) and in the daily intake of nonsteroidal antiinflammatory drugs (P < 0.01). The well‐known immunosuppressive action of androgens probably contributed to our findings in these RA patients.
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Case reports and randomised controlled trials of androgen therapy in inflammatory diseases such as rheumatoid arthritis or systemic lupus erythematosus have found androgens improve clinical status and reduce inflammatory markers.
“There are several case reports and randomised controlled trials of androgen therapy in patients with inflammatory disease such as rheumatoid arthritis or systemic lupus erythematosus in which androgens have been found to improve clinical status and reduce inflammatory markers.[33][34][35]”
From Testosterone replacement in hypogonadal men with angina improves ischaemic threshold and quality of life (2004) · cites this paper as [33]
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References 32 · Cited by 209
- Authors
- Cutolo, M., Balleari, E., Giusti, M., Intra, E., & Accardo, S.
- Affiliations
- University of Genoa (IT)
- Corresponding author
- Cutolo, Maurizio
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 1991-01
- Volume
- 34
- Issue
- 1
- Pages
- 1-5
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2036599085
- Cited by
- 209
- References
- 32
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 2 · 2015: 2 · 2014: 6 · 2013: 5 · 2012: 6
- FWCI
- 4.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Arthritis & Rheumatism (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- testosterone replacement therapy, testosterone undecanoate, hypogonadism, androgen deficiency, CD8+ T cells, CD4/CD8 ratio, rheumatoid factor, immunosuppression, nonsteroidal anti-inflammatory drugs
- MeSH terms
- Administration, Oral, Aged, Androgens, Arthritis, Rheumatoid, Dehydroepiandrosterone, Follicle Stimulating Hormone, Humans, Luteinizing Hormone, Male, Middle Aged, Testosterone, Lymphocyte Subsets
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