Correlation of serum interleukin-6 levels with joint involvement and thrombocytosis in systemic juvenile rheumatoid arthritis
Abstract
We measured interleukin-6 (IL-6) levels in 70 serum samples obtained from 25 patients with systemic-onset juvenile rheumatoid arthritis (JRA), using the hybridoma cell line B9. Patients with systemic-onset JRA had significantly elevated serum IL-6 levels during active disease (mean +/- SD 92.1 +/- 75.1 hybridoma growth factor units/ml; P less than 0.00001 versus healthy age-matched controls), but not during remission. Serum IL-6 levels correlated with the extent and severity of joint involvement (P less than 0.001) and with platelet counts (P less than 0.05). Our data suggest that IL-6 plays a significant role in the pathogenesis of systemic-onset JRA.
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There is a correlation between IL-6 and the severity of RA and other inflammatory and autoimmune diseases.
“In line with this notion, there is a correlation between IL-6 and the severity of RA and other inflammatory and autoimmune diseases (3, 260, 261).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [260]
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References 15 · Cited by 358
- Authors
- de Benedetti, F., Massa, M., Robbioni, P., Ravelli, A., Burgio, G. R., & Martini, A.
- Affiliations
- University of Pavia (IT)
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 1991-10-07
- Volume
- 34
- Issue
- 9
- Pages
- 1158-1163
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W1994860638
- Cited by
- 358
- References
- 15
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 9 · 2021: 13 · 2020: 8 · 2019: 22 · 2018: 8 · 2017: 17 · 2016: 16 · 2015: 20 · 2014: 16 · 2013: 15 · 2012: 22
- FWCI
- 4.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Arthritis & Rheumatism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Keywords
- interleukin-6, systemic juvenile idiopathic arthritis, serum cytokine levels, joint involvement, thrombocytosis, platelet count, disease activity, remission, pathogenesis
- MeSH terms
- Adolescent, Arthritis, Juvenile, Child, Child, Preschool, Humans, Joints, Thrombocytosis, Interleukin-6
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