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A revised estimate of twin concordance in systemic lupus erythematosus
Abstract
Objective. Based on a small clinical series and previously published case reports, concordance for systemic lupus erythematosus (SLE) among monozygous (MZ) twins has been reported to be as high as 69%. Using a larger and less biased sample, we provide another estimate of this percentage. Methods. We established a registry of twins with SLE, based upon self‐reports and information provided by the patients' physicians. We used DNA fingerprinting to validate the reported zygosity in a sample of these twins. Results. Of 107 twin pairs meeting the American College of Rheumatology 1982 revised criteria for the diagnosis of SLE, 24% of 45 MZ pairs and 2% of 62 dizygous (DZ) pairs were concordant. The frequency distributions of diagnostic criteria and disease symptoms in the SLE patients were similar to those in other published reports of SLE patients. Zygosity was confirmed by DNA fingerprinting in a subsample of 15 self‐described MZ twins and 7 self‐described DZ twins. AH individuals had correctly predicted their zygosity. Conclusion. MZ concordance for SLE is similar to that for other autoimmune diseases and is much lower than previously believed.
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Cited by
The International Consortium for Systemic Lupus Erythematosus Genetics (SLEGEN), Harley, J. B., Alarcón-Riquelme, M. E., Criswell, L. A., Jacob, C. O., Kimberly, R. P., Moser, K. L., Tsao, B. P., Vyse, T. J., & Langefeld, C. D. (2008) · Nature Genetics · doi:10.1038/ng.81 · Cited by 1,309
Bentham, J., Morris, D. L., Cunninghame Graham, D. S., Pinder, C. L., Tombleson, P., Behrens, T. W., Martín, J., Fairfax, B. P., Knight, J. C., Chen, L., et al. (2015) · Nature Genetics · doi:10.1038/ng.3434 · Cited by 1,020
Molecular mimicry and autoimmunity
Rojas, M., Restrepo-Jiménez, P., Monsalve, D. M., Pacheco, Y., Acosta-Ampudia, Y., Ramírez-Santana, C., Leung, P. S. C., Ansari, A. A., Gershwin, M. E., & Anaya, J.-M. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.10.012 · Cited by 627
A genetic basis for familial aggregation in multiple sclerosis
Ebers, G. C., Sadovnick, A. D., & Risch, N. J. (1995) · Nature · doi:10.1038/377150a0 · Cited by 615
The Role of Complement in the Development of Systemic Lupus Erythematosus
Manderson, A. P., Botto, M., & Walport, M. J. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104549 · Cited by 538
Metadata
- Authors
- Deafen, D., Escalante, A., Weinrib, L., Horwitz, D., Bachman, B., Roy‐Burman, P., Walker, A., & Mack, T. M.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 1992-03
- Volume
- 35
- Issue
- 3
- Pages
- 311-318
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2127983802
- Cited by
- 777
- References
- 0
- FWCI
- 13.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Deafen, D., Escalante, A., Weinrib, L., Horwitz, D., Bachman, B., Roy‐Burman, P., Walker, A., & Mack, T. M. (1992). A revised estimate of twin concordance in systemic lupus erythematosus. Arthritis & Rheumatism. https://doi.org/10.1002/art.1780350310
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