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A randomized, double‐blind, placebo‐controlled study of cd4 monoclonal antibody therapy in early rheumatoid arthritis
Abstract
Objective. To assess the efficacy of the CD4 monoclonal antibody (MAb) cM‐T412 in the treatment of early rheumatoid arthritis (RA). Methods. Sixty patients were enrolled in a 6‐week randomized, double‐blind, placebo‐controlled study investigating multiple dose regimens of cM‐T412. Thirty patients subsequently were enrolled in a 9‐month randomized, double‐blind, placebo‐controlled study investigating monthly single‐dose administrations of cM‐T412. Results. Analysis of clinical parameters revealed no changes in arthritis activity in the groups that received CD4 MAb or the placebo group, and no difference between the groups, in either in the first or the second part of the study. The number of circulating CD4+ cells decreased substantially in the patients treated with CD4 MAb. Conclusion. CD4 MAb treatment of patients with early RA induced no therapeutic effect.
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Cited by
Diagnosis and Management of Rheumatoid Arthritis: A Review
Aletaha, D., & Smolen, J. S. (2018) · JAMA · doi:10.1001/jama.2018.13103 · Cited by 2,313
Elliott, M. J., Maini, R. N., Feldmann, M., Kalden, J. R., Antoni, C., Smolen, J. S., Leeb, B., Breedveld, F. C., Macfarlane, J. D., Bijl, J. A., et al. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90628-9 · Cited by 1,682
Self-citationTak, P. P., Taylor, P. C., Breedveld, F. C., Smeets, T. J. M., Daha, M. R., Kluin, P. M., Meinders, A. E., & Maini, R. N. (1996) · Arthritis & Rheumatism · doi:10.1002/art.1780390702 · Cited by 377
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Metadata
- Authors
- Van Der Lubbe, P. A., Dijkmans, B. A. C., Markusse, H. M., Nässander, U., & Breedveld, F. C.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 1995-08
- Volume
- 38
- Issue
- 8
- Pages
- 1097-1106
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2081935520
- Cited by
- 195
- References
- 0
- FWCI
- 14.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A randomized, double‐blind, placebo‐controlled study of cd4 monoclonal antibody therapy in early rheumatoid arthritis. https://app.cochat.ai/papers/10.1002/art.1780380812
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- Van Der Lubbe, P. A., Dijkmans, B. A. C., Markusse, H. M., Nässander, U., & Breedveld, F. C. (1995). A randomized, double‐blind, placebo‐controlled study of cd4 monoclonal antibody therapy in early rheumatoid arthritis. Arthritis & Rheumatism. https://doi.org/10.1002/art.1780380812
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