The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Endothelial cells as target for antiphospholipid antibodies. Human Polyclonal and Monoclonal Anti‐β2‐Glycoprotein I Antibodies React In Vitro with Endothelial Cells Through Adherent β2‐Glycoprotein I and Induce Endothelial Activation
Abstract
Objective. To investigate the ability of human anti‐β 2‐glycoprotein I (anti‐β 2 GPI) antibodies to recognize the cofactor adherent on endothelial cells (EC) and to modulate endothelial functions. Methods. Six human affinity‐purified polyclonal anti‐β 2 GPI IgG and 2 IgM monoclonal antibodies (MAb) were obtained from patients with the antiphos‐pholipid syndrome. The antibodies were tested for their ability to 1) bind to endothelial monolayers through the adherent β 2 GPI and 2) modulate endothelial adhesion molecule expression and interleukin‐6 (IL‐6) and 6‐keto‐prostaglandin F 1α (6‐keto‐PGF 1α) secretion. Results. The affinity‐purified IgG and the MAb with anti‐β 2 GPI activity, but not the respective controls, displayed EC binding, which declined on cells incubated in serum‐free medium and was restored in a dose‐dependent manner by exogenous human β 2 GPI. After EC binding, both polyclonal and monoclonal antibodies up‐regulated adhesion molecule expression. Anti‐β 2 GPI MAb also significantly increased IL‐6 and 6‐keto‐PGF 1α secretion. Conclusion. These findings support the hypothesis that anti‐β 2 GPI antibodies bind and activate EC through the adherent cofactor β 2 GPI, likely leading to a procoagulant state.
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Cited by
Raschi, E., Testoni, C., Bosisio, D., Borghi, M. O., Koike, T., Mantovani, A., & Meroni, P. L. (2003) · Blood · doi:10.1182/blood-2002-08-2349 · Cited by 306
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Metadata
- Authors
- Papa, N. D., Guidali, L., Sala, A., Buccellati, C., Khamashta, M. A., Ichikawa, K., Koike, T., Balestrieri, G., Tincani, A., Hughes, G. R. V., & Meroni, P. L.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 1997-03
- Volume
- 40
- Issue
- 3
- Pages
- 551-561
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2002709892
- Cited by
- 289
- References
- 46
- FWCI
- 14.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Endothelial cells as target for antiphospholipid antibodies. Human Polyclonal and Monoclonal Anti‐β2‐Glycoprotein I Antibodies React In Vitro with Endothelial Cells Through Adherent β2‐Glycoprotein I and Induce Endothelial Activation. https://app.cochat.ai/papers/10.1002/art.1780400322
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- Papa, N. D., Guidali, L., Sala, A., Buccellati, C., Khamashta, M. A., Ichikawa, K., Koike, T., Balestrieri, G., Tincani, A., Hughes, G. R. V., & Meroni, P. L. (1997). Endothelial cells as target for antiphospholipid antibodies. Human Polyclonal and Monoclonal Anti‐β2‐Glycoprotein I Antibodies React In Vitro with Endothelial Cells Through Adherent β2‐Glycoprotein I and Induce Endothelial Activation. Arthritis & Rheumatism. https://doi.org/10.1002/art.1780400322
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