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Azathioprine in Behçet's syndrome. Effects on long‐term prognosis
Abstract
Objective. To assess the effect of azathioprine (AZA) treatment on long‐term prognosis in Behçet's syndrome. Methods. Patients (all male) who took part in a double‐blind, placebo‐controlled trial of AZA a mean ± SD of 94 ± 10 months previously were reevaluated. Results. The emergence of blindness (log rank χ 2 = 5.6, P = 0.02) and a 2‐line drop in the visual acuity of the right eye (log rank χ 2 = 5.9, P = 0.015) occurred significantly more frequently among the patients originally allocated to the placebo group compared with patients who originally received AZA, despite posttrial treatment for patients in both groups when needed. There was also a trend toward more frequent occurrence of extraocular complications in the placebo group. The beneficial effect of AZA was especially pronounced among patients who had eye involvement of short duration prior to their entry into the trial. Conclusion. Early treatment with AZA tends to favorably affect the long‐term prognosis of Behçet's syndrome.
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Cited by
Uveitis in Behçet disease: An analysis of 880 patients
Tugal-Tutkun, I., Onal, S., Altan-Yaycioglu, R., Huseyin Altunbas, H., & Urgancioglu, M. (2004) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2004.03.022 · Cited by 631
Behçet's disease – a contemporary review
Mendes, D., Correia, M., Barbedo, M., Vaio, T., Mota, M., Gonçalves, O., & Valente, J. (2009) · Journal of Autoimmunity · doi:10.1016/j.jaut.2009.02.011 · Cited by 320
Galor, A., Jabs, D. A., Leder, H. A., Kedhar, S. R., Dunn, J. P., Peters, G. B., & Thorne, J. E. (2008) · Ophthalmology · doi:10.1016/j.ophtha.2008.04.026 · Cited by 217
Metadata
- Authors
- Hamuryudan, V., Özyazgan, Y., Hizli, N., Mat, C., Yurdakul, S., Tüzün, Y., Şlenocak, M., & Yazici, H.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 1997-04
- Volume
- 40
- Issue
- 4
- Pages
- 769-774
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2156195056
- Cited by
- 280
- References
- 0
- FWCI
- 13.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hamuryudan, V., Özyazgan, Y., Hizli, N., Mat, C., Yurdakul, S., Tüzün, Y., Şlenocak, M., & Yazici, H. (1997). Azathioprine in Behçet's syndrome. Effects on long‐term prognosis. Arthritis & Rheumatism. https://doi.org/10.1002/art.1780400425
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