The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Treatment of early Rheumatoid Arthritis with minocycline or placebo. Results of a Randomized, double‐blind, placebo‐controlled trial
Open accessAbstract
Objective. To determine if minocycline is an effective therapy for seropositive rheumatoid arthritis (RA) when used within the first year of disease. Methods. The Rheumatoid Arthritis Investigational Network enrolled 46 patients with RA of <1 year duration into a 6‐month study of minocycline (100 mg twice daily) versus placebo. All patients were rheumatoid factor positive. The primary end point of the study was successful completion of 6 months of treatment with no drug toxicity while maintaining 50% improvement in composite symptoms of arthritis. Results. Eighteen of the 46 patients who were enrolled met 50% improvement criteria at 3 months, and maintained at least a 50% improvement for 6 months with no significant drug toxicity. Among them were 15 of the 23 patients (65%) treated with minocycline and 3 of 23 patients (13%) treated with placebo (P < 0.001). Conclusion. In patients with early seropositive RA, therapy with minocycline is superior to placebo.
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Elliott, M. J., Maini, R. N., Feldmann, M., Kalden, J. R., Antoni, C., Smolen, J. S., Leeb, B., Breedveld, F. C., Macfarlane, J. D., Bijl, J. A., et al. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90628-9 · Cited by 1,682
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Forbes, J. D., Van Domselaar, G., & Bernstein, C. N. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01081 · Cited by 429
Periodontitis and Rheumatoid Arthritis: A Review
Bartold, P. M., Marshall, R. I., & Haynes, D. R. (2005) · Journal of Periodontology · doi:10.1902/jop.2005.76.11-s.2066 · Cited by 285
Treatment of rheumatoid arthritis
Gaffo, A., Saag, K. G., & Curtis, J. R. (2006) · American Journal of Health-System Pharmacy · doi:10.2146/ajhp050514 · Cited by 266
Mangat, P., Wegner, N., Venables, P. J., & Potempa, J. (2010) · Arthritis Research & Therapy · doi:10.1186/ar3000 · Cited by 111
Rapamycin‐mediated mouse lifespan extension: Late‐life dosage regimes with sex‐specific effects
Strong, R., Miller, R. A., Bogue, M., Fernandez, E., Javors, M. A., Libert, S., Marinez, P. A., Murphy, M. P., Musi, N., Nelson, J. F., et al. (2020) · Aging Cell · doi:10.1111/acel.13269 · Cited by 92
Metadata
- Authors
- O'Dell, J. R., Haire, C. E., Palmer, W., Drymalski, W., Wees, S., Blakely, K., Churchill, M., Eckhoff, P. J., Weaver, A., Doud, D., Erikson, N., Dietz, F., Olson, R., Maloley, P., Klassen, L. W., & Moore, G. F.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 1997-05
- Volume
- 40
- Issue
- 5
- Pages
- 842-848
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2104243819
- Cited by
- 177
- References
- 1
- FWCI
- 10.36
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Treatment of early Rheumatoid Arthritis with minocycline or placebo. Results of a Randomized, double‐blind, placebo‐controlled trial. https://app.cochat.ai/papers/10.1002/art.1780400510
- The paper
- O'Dell, J. R., Haire, C. E., Palmer, W., Drymalski, W., Wees, S., Blakely, K., Churchill, M., Eckhoff, P. J., Weaver, A., Doud, D., Erikson, N., Dietz, F., Olson, R., Maloley, P., Klassen, L. W., & Moore, G. F. (1997). Treatment of early Rheumatoid Arthritis with minocycline or placebo. Results of a Randomized, double‐blind, placebo‐controlled trial. Arthritis & Rheumatism. https://doi.org/10.1002/art.1780400510
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
