The ratio of circulating osteoprotegerin to RANKL in early rheumatoid arthritis predicts later joint destruction

Geusens, P. P.; Landewé, R. B. M.; Garnero, P.; Chen, D.; Dunstan, C. R.; Lems, W. F.; Stinissen, P.; van der Heijde, D. M. F. M.; van der Linden, S.; Boers, M.

doi:10.1002/art.21896

The ratio of circulating osteoprotegerin to RANKL in early rheumatoid arthritis predicts later joint destruction

Objective Rheumatoid arthritis (RA) is a chronic inflammatory disease that may result in debilitating joint deformities with destruction of bone and cartilage. Inflammation is still considered the pivotal inducer of both components of joint damage. Results of recent animal studies suggested a pro…