T cell polarization identifies distinct clinical phenotypes in scleroderma lung disease

Objective Lung involvement is the leading cause of morbidity and mortality in systemic sclerosis (SSc; scleroderma), and interstitial lung disease (ILD) is the most common pulmonary manifestation. An abnormal profibrotic Th2/Tc2‐polarized T cell response is postulated to mediate tissue damage and…