Endothelin 1 contributes to the effect of transforming growth factor β1 on wound repair and skin fibrosis

Lagares, David; García‐Fernández, Rosa Ana; Jiménez, Clara López; Magán‐Marchal, Noemi; Busnadiego, Oscar; Lamas, Santiago; Rodríguez‐Pascual, Fernando

doi:10.1002/art.27307

Endothelin 1 contributes to the effect of transforming growth factor β1 on wound repair and skin fibrosis

Objective To characterize the pathways induced by transforming growth factor β1 (TGFβ1) that lead to the expression of endothelin 1 (ET‐1) in human dermal fibroblasts, and to study the effects of TGFβ1 and ET‐1 on the acquisition of a profibrotic phenotype and assess the contribution of the TGFβ1…