The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Pattern on the antinuclear antibody–HEp‐2 test is a critical parameter for discriminating antinuclear antibody–positive healthy individuals and patients with autoimmune rheumatic diseases
Open accessAbstract
Objective: To identify features of antinuclear antibody (ANA)–HEp‐2 test results that discriminate ANA‐positive healthy individuals and patients with autoimmune rheumatic diseases (ARDs). Methods: We sequentially retrieved data on 918 healthy individuals and 153 patients with ARDs after clinical assessment. ANA‐positive healthy individuals for whom data were available were reevaluated after 3.6–5.0 years. An ANA–HEp‐2 test result was considered positive when a clear ANA pattern was observed at 1:80 dilution in 2 distinct commercial HEp‐2 slides by 2 blinded independent observers. Results: ANAs were present in 118 healthy individuals (12.9%) and 138 patients with ARDs (90.2%). The ANA titer was higher in patients with ARDs than in healthy individuals ( P < 0.001). The ANA pattern profile was distinct in the 2 groups. Nuclear homogeneous, nuclear coarse speckled, and nuclear centromeric patterns appeared exclusively in patients with ARDs. The nuclear dense fine speckled pattern occurred only in healthy individuals. The most frequent ANA pattern in both groups was the nuclear fine speckled pattern, which occurred at lower titer in healthy individuals than in patients with ARDs ( P < 0.001). Anti–extractable nuclear antigen was present in 1 healthy individual (anti‐SSA/Ro) and in 52 patients with ARDs (37.7%). None of the 40 reevaluated healthy individuals developed ARDs, and 29 (72.5%) remained ANA positive. All healthy individuals who became ANA negative had an ANA titer of 1:80 at baseline. Conclusion: Our findings suggest that the titer, and especially the pattern, on the ANA–HEp‐2 test strongly enhances our ability to discriminate ANA‐positive healthy individuals and patients with ARDs.
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Hochberg, M. C. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780400928 · Cited by 11,409
Vitali, C., Bombardieri, S., Jonsson, R., Moutsopoulos, H. M., Alexander, E. L., Carsons, S. E., Daniels, T. E., Fox, P. C., Fox, R. I., Kassan, S. S., et al. (2002) · Annals of the Rheumatic Diseases · doi:10.1136/ard.61.6.554 · Cited by 5,299
Polymyositis and Dermatomyositis: (First of Two Parts)
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Preliminary criteria for the classification of systemic sclerosis (scleroderma)
Masi, A. T., & Subcommittee For Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee (1980) · Arthritis & Rheumatism · doi:10.1002/art.1780230510 · Cited by 4,898
Development of Autoantibodies before the Clinical Onset of Systemic Lupus Erythematosus
Arbuckle, M. R., McClain, M. T., Rubertone, M. V., Scofield, R. H., Dennis, G. J., James, J. A., & Harley, J. B. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021933 · Cited by 2,578
Nielen, M. M. J., van Schaardenburg, D., Reesink, H. W., van de Stadt, R. J., van der Horst‐Bruinsma, I. E., de Koning, M. H. M. T., Habibuw, M. R., Vandenbroucke, J. P., & Dijkmans, B. A. C. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20018 · Cited by 1,861
Range of antinuclear antibodies in “healthy” individuals
Tan, E. M., Feltkamp, T. E. W., Smolen, J. S., Butcher, B., Dawkins, R., Fritzler, M. J., Gordon, T., Hardin, J. A., Kalden, J. R., Lahita, R. G., et al. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780400909 · Cited by 702
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Evidence‐based guidelines for the use of immunologic tests: Antinuclear antibody testing
Solomon, D. H., Kavanaugh, A. J., Schur, P. H., & American College of Rheumatology Ad Hoc Committee on Immunologic Testing Guidelines (2002) · Arthritis Care & Research · doi:10.1002/art.10561 · Cited by 510
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Cited by
Agmon-Levin, N., Damoiseaux, J., Kallenberg, C., Sack, U., Witte, T., Herold, M., Bossuyt, X., Musset, L., Cervera, R., Plaza-Lopez, A., et al. (2014) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2013-203863 · Cited by 615
Self-citationDamoiseaux, J., Andrade, L. E. C., Carballo, O. G., Conrad, K., Francescantonio, P. L. C., Fritzler, M. J., Garcia de la Torre, I., Herold, M., Klotz, W., Cruvinel, W. D. M., et al. (2019) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2018-214436 · Cited by 378
Self-citationLeuchten, N., Hoyer, A., Brinks, R., Schoels, M., Schneider, M., Smolen, J., Johnson, S. R., Daikh, D., Dörner, T., Aringer, M., et al. (2018) · Arthritis Care & Research · doi:10.1002/acr.23292 · Cited by 190
Strategies for building reference standards for autoantibodies
Sheldon, J., & Dellavance, A. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00194 · Cited by 20
Self-citationAntimitochondrial rather than antinuclear antibodies correlate with severe drug-induced liver injury
Weber, S., Benesic, A., Buchholtz, M.-L., Rotter, I., & Gerbes, A. L. (2021) · Digestive Diseases · doi:10.1159/000511635 · Cited by 17
Metadata
- Authors
- Mariz, H. A., Sato, E. I., Barbosa, S. H., Rodrigues, S. H., Dellavance, A., & Andrade, L. E. C.
- Venue
- Arthritis & Rheumatism
- Publisher
- Wiley
- Published
- 2010-12-28
- Volume
- 63
- Issue
- 1
- Pages
- 191-200
- ISSN
- 0004-3591 (ISSN-L)
- 1529-0131
- OpenAlex
- W2122657747
- Cited by
- 347
- References
- 36
- FWCI
- 9.03
- Type
- journal article
- Language
- en
- Open access
- green
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