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Cited by 1,042

The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.

2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis

Fraenkel, Liana, Bathon, Joan M., England, Bryant R., St.Clair, E. William, Arayssi, Thurayya, Carandang, Kristine, Deane, Kevin D., Genovese, Mark, Huston, Kent Kwas, Kerr, Gail, Kremer, Joel, Nakamura, Mary C., Russell, Linda A., Singh, Jasvinder A., Smith, Benjamin J., Sparks, Jeffrey A., Venkatachalam, Shilpa, Weinblatt, Michael E., Al‐Gibbawi, Mounir, Baker, Joshua F., Barbour, Kamil E., Barton, Jennifer L., Cappelli, Laura, Chamseddine, Fatimah, George, Michael, Johnson, Sindhu R., Kahale, Lara, Karam, Basil S., Khamis, Assem M., Navarro-Millán, Iris, Mirza, Reza, Schwab, Pascale, Singh, Namrata, Turgunbaev, Marat, Turner, Amy S., Yaacoub, Sally, Akl, Elie A.·2021·Arthritis & Rheumatology

Abstract

Objective: To develop updated guidelines for the pharmacologic management of rheumatoid arthritis. Methods: We developed clinically relevant population, intervention, comparator, and outcomes (PICO) questions. After conducting a systematic literature review, the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used to rate the certainty of evidence. A voting panel comprising clinicians and patients achieved consensus on the direction (for or against) and strength (strong or conditional) of recommendations. Results: The guideline addresses treatment with disease‐modifying antirheumatic drugs (DMARDs), including conventional synthetic DMARDs, biologic DMARDs, and targeted synthetic DMARDs, use of glucocorticoids, and use of DMARDs in certain high‐risk populations (i.e., those with liver disease, heart failure, lymphoproliferative disorders, previous serious infections, and nontuberculous mycobacterial lung disease). The guideline includes 44 recommendations (7 strong and 37 conditional). Conclusion: This clinical practice guideline is intended to serve as a tool to support clinician and patient decision‐making. Recommendations are not prescriptive, and individual treatment decisions should be made through a shared decision‐making process based on patients’ values, goals, preferences, and comorbidities.

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Authors
Fraenkel, L., Bathon, J. M., England, B. R., St.Clair, E. W., Arayssi, T., Carandang, K., Deane, K. D., Genovese, M., Huston, K. K., Kerr, G., Kremer, J., Nakamura, M. C., Russell, L. A., Singh, J. A., Smith, B. J., Sparks, J. A., Venkatachalam, S., Weinblatt, M. E., Al‐Gibbawi, M., Baker, J. F., Barbour, K. E., Barton, J. L., Cappelli, L., Chamseddine, F., George, M., Johnson, S. R., Kahale, L., Karam, B. S., Khamis, A. M., Navarro-Millán, I., Mirza, R., Schwab, P., Singh, N., Turgunbaev, M., Turner, A. S., Yaacoub, S., & Akl, E. A.
Venue
Arthritis & Rheumatology
Publisher
Wiley
Published
2021-06-08
Volume
73
Issue
7
Pages
1108-1123
ISSN
  • 2326-5191 (ISSN-L)
  • 2326-5205
OpenAlex
W4232642069
Cited by
1,042
References
56
FWCI
94.94
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: 2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis. https://app.cochat.ai/papers/10.1002/art.41752
The paper
Fraenkel, L., Bathon, J. M., England, B. R., St.Clair, E. W., Arayssi, T., Carandang, K., Deane, K. D., Genovese, M., Huston, K. K., Kerr, G., Kremer, J., Nakamura, M. C., Russell, L. A., Singh, J. A., Smith, B. J., Sparks, J. A., Venkatachalam, S., Weinblatt, M. E., Al‐Gibbawi, M., . . . Akl, E. A. (2021). 2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis. Arthritis & Rheumatology. https://doi.org/10.1002/art.41752

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.